ArticleNeuroImage2020
Mapping critical cortical hubs and white matter pathways by direct electrical stimulation: an original functional atlas of the human brain.
Article in NeuroImage, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 100 papers, 7 of them syntheses that pooled it.
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Who cites it
100 citing papers in PubMed, 7 syntheses or guidelines pooled it, 194 citations in OpenAlex.
- A probabilistic map of motor and cognitive functions: a meta-analysis of 4325 stimulation sites.Brain structure & function · 2025Pooled it
- Intraoperative mapping of the right hemisphere: a systematic review of protocols that evaluate cognitive and social cognitive functions.Frontiers in psychology · 2024Pooled it
- Preoperative assessment of eloquence in neurosurgery: a systematic review.Journal of neuro-oncology · 2023Pooled it
- Localization patterns of speech and language errors during awake brain surgery: a systematic review.Neurosurgical review · 2023Pooled it
- Application of diffusion tensor imaging in the diagnosis of post-stroke aphasia: a meta-analysis and systematic review.Frontiers in psychology · 2023Pooled it
- White matter variability, cognition, and disorders: a systematic review.Brain structure & function · 2022Pooled it
- Extent of resection in diffuse low-grade gliomas and the role of tumor molecular signature-a systematic review of the literature.Neurosurgical review · 2021Pooled it
- A neural architecture for imagined and overt speech motor dynamics.Nature neuroscience · 2026Article
- Unveiling Functional Architecture of Human Thalamus: AStereoelectroencephalography Study.MedComm · 2026Article
- A cortical gradient in area 55b links language and somato-cognitive action networks.Research square · 2026Article
- The prefrontal cortex across scales: laminar architecture, white-matter constraints, and distributed control in cognition.Brain structure & function · 2026Review
- Widespread white matter microstructural abnormalities in treatment‑naïve patients with first‑episode schizophrenia revealed by fixel-based analysis.Translational psychiatry · 2026Article
- Analysis of recovery-related white matter microstructures in visual spatial neglect based on diffusion tensor imaging.Brain imaging and behavior · 2026Article
- The future of neurosurgical oncology lies in cognitive neurosciences: understanding brain processing is much more valuable than surgical technology.Frontiers in oncology · 2026Article
- A novel high-resolution test battery for language mapping in awake craniotomy: preliminary perioperative results in neurooncologic patients.Frontiers in oncology · 2026Article
- EStiMapp: A practical tool for mapping clinical symptoms evoked by electrical stimulation in intracranial EEG for epilepsy surgery.Clinical neurophysiology practice · 2026Article
- Surgical decision making in the era of supramarginal glioma resections: a current perspective and narrative review.CNS oncology · 2025Review
- Preoperative Brain Mapping Predicts Language Outcomes After Eloquent Tumor Resection.Human brain mapping · 2025Article
- Integrating direct electrical stimulation with brain connectivity predicts lesion-induced language impairment and recovery.Communications medicine · 2025Article
- A probabilistic functional atlas based on extraoperative electrocortical stimulation mapping.bioRxiv : the preprint server for biology · 2025Article
40 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 6 institutions in 3 countries.
Funding
Abstract
objectiveThe structural and functional organization of brain networks subserving basic daily activities (i.e. language, visuo-spatial cognition, movement, semantics, etc.) are not completely understood to date. Here, we report the first probabilistic cortical and subcortical atlas of critical structures mediating human brain functions based on direct electrical stimulation (DES), a well-validated tool for the exploration of cerebral processing and for performing safe surgical interventions in eloquent areas.
methodsWe collected 1162 cortical and 659 subcortical DES responses during testing of 16 functional domains in 256 patients undergoing awake surgery. Spatial coordinates for each functional response were calculated, and probability distributions for the entire patient cohort were mapped onto a standardized three-dimensional brain template using a multinomial statistical analysis. In addition, matching analyses were performed against prior established anatomy-based cortical and white matter (WM) atlases.
resultsThe probabilistic maps for each functional domain were provided. The topographical analysis demonstrated a wide spatial distribution of cortical functional responses, while subcortical responses were more restricted, localizing to known WM pathways. These DES-derived data showed reliable matching with existing cortical and WM atlases as well as recent neuroimaging and neurophysiological data.
conclusionsWe present the first integrated and comprehensive cortical-subcortical atlas of structures essential for humans' neural functions based on highly-specific DES mapping during real-time neuropsychological testing. This novel atlas can serve as a complementary tool for neuroscientists, along with data obtained from other modalities, to improve and refine our understanding of the functional anatomy of critical brain networks.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.