ArticleBehavioural brain research2020
Effects of chronic intermittent ethanol exposure during early and late adolescence on anxiety-like behaviors and behavioral flexibility in adulthood.
Article in Behavioural brain research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 1 of them a synthesis that pooled it.
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Who cites it
62 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Adolescent Alcohol and Stress Exposure Rewires Key Cortical Neurocircuitry.Frontiers in neuroscience · 2022Pooled it
- Peri-adolescent ethanol exposure differentially affects mechanical and thermal sensitivity in rats.The journal of pain · 2026Article
- Adolescent ethanol exposure reduces central amygdala GABA transmission but preserves noradrenergic signaling in adulthood.Neuropharmacology · 2026Article
- Sex differences in compulsive alcohol drinking phenotypes: implications for decision-making and social behavior in a preclinical model.Psychopharmacology · 2026Article
- Epigenetic Repression of the Serotonergic Neuron Phenotype Following Adolescent Binge Drinking Is Restored through Inhibition of Proinflammatory Signaling by Exercise and Glycyrrhizic Acid.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Glutamatergic dysfunction of astrocytes in paraventricular nucleus of thalamus contributes to adult anxiety susceptibility in adolescent ethanol exposed mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Prenatal antioxidant treatment suppresses maternal immune activation induced increases in alcohol self-administration in a sex-specific manner.Psychopharmacology · 2026Article
- Socio-cultural context as a protective factor: regional disparities in adolescent mental health in Mexico during the COVID-19 pandemic.Frontiers in child and adolescent psychiatry · 2026Article
- Adolescent ethanol sensitivity may predict temporal patterns of anxiety-like behavior following ethanol withdrawal in male rats.The American journal of drug and alcohol abuse · 2026Article
- Adolescent social isolation associated changes in ethanol-induced dopamine regulation in the ventral pallidum.Addiction neuroscience · 2025Article
- The Impacts of Binge Drinking and Hangover on the Social Brain: An Integrative Narrative Review.Biomedicines · 2025Review
- Adolescent alcohol consumption alters sex-specific behaviors associated with prefrontal functional connectivity in mice.bioRxiv : the preprint server for biology · 2025Article
- Sex-dependent effects of ethanol withdrawal from a single- and repeated binge episode exposures on social anxiety-like behavior and neuropeptide gene expression in adolescent rats.Alcohol (Fayetteville, N.Y.) · 2025Article
- Adolescent intermittent ethanol exposure induces sex-specific and time-dependent changes in affective behaviors and metabolomic profiles.Frontiers in behavioral neuroscience · 2025Article
- Prelimbic cortex perineuronal net expression and social behavior: Impact of adolescent intermittent ethanol exposure.Neuropharmacology · 2025Article
- Adolescent Alcohol Exposure Dysregulates Developing Cortical GABA Circuits.Advances in experimental medicine and biology · 2025Review
- Alcohol, flexible behavior, and the prefrontal cortex: Functional changes underlying impaired cognitive flexibility.Neuropharmacology · 2024Review
- Neonatal paw pricking alters adolescent behavior in a sex-dependent manner and sucrose partially remediates the effects.Physiology & behavior · 2024Article
- Patterns of neuronal activation following ethanol-induced social facilitation and social inhibition in adolescent cFos-LacZ male and female rats.Behavioural brain research · 2024Article
- Effects of adolescent intermittent ethanol exposure on cortical perineuronal net and parvalbumin expression in adulthood mediate behavioral inflexibility.Alcohol, clinical & experimental research · 2024Article
2 more citing papers are in PubMed but not listed here.
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5 authors.
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Abstract
Although both humans and laboratory rodents demonstrate cognitive and affective alterations associated with adolescent alcohol exposure, it is still unknown whether the consequences of early initiation of alcohol use differ from those of later binge drinking within the adolescent developmental period. The present study was designed to assess the effects of early and late AIE on (1) anxiety-like behavior under social (modified social interaction test) and non-social test circumstances (modified light/dark box test, elevated plus maze), and (2) behavioral flexibility, indexed via set shifting in males and females. Early-mid adolescent intermittent exposure (early AIE) occurred between postnatal days (P) 25 and 45, whereas late adolescent intermittent exposure (late AIE) was conducted between P45 and P65, with behavioral testing initiated not earlier than 25 days after repeated exposure to ethanol (4.0 g/kg intragastrically, every other day for a total of 11 exposures). Anxiety-like behavior on the EPM was evident in males and females following early AIE, whereas only males demonstrated non-social anxiety on the EPM following late AIE. Social anxiety-like alterations and deficits in behavioral flexibility were evident only in males following early AIE. Taken together, the results of the present study demonstrate a particular vulnerability of young adolescent males to long-lasting detrimental effects of repeated ethanol and an insensitivity of older adolescent females to the intermittent ethanol exposure paradigm.
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