Evidence map›Paper›PMID 31626845›Full record

ArticleJournal of neuroscience methods2020

Implantable wireless device for study of entrapment neuropathy.

Ronit Malka, Diego L Guarin, Suresh Mohan, Iván Coto Hernández, Pavel Gorelik, Ofer Mazor, Tessa Hadlock, Nate Jowett

Open access · greenAbstract readValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroscience methods, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. A sheep model of chronic cervical compressive myelopathy via an implantable wireless compression device.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Ronit MalkaHealth Science and Technology Division, Harvard Medical School/Massachusetts Institute of Technology, Boston, MA, USA; Surgical Photonics and Engineering Laboratory, Department of Otolaryngology - Head and Neck Surgery, Massachusetts Eye and Ear and Harvard Medical School, Boston, MA, USA. Electronic address: ronit.e.malka.mil@mail.mil.
Diego L GuarinSurgical Photonics and Engineering Laboratory, Department of Otolaryngology - Head and Neck Surgery, Massachusetts Eye and Ear and Harvard Medical School, Boston, MA, USA.
Suresh MohanSurgical Photonics and Engineering Laboratory, Department of Otolaryngology - Head and Neck Surgery, Massachusetts Eye and Ear and Harvard Medical School, Boston, MA, USA.
Iván Coto HernándezSurgical Photonics and Engineering Laboratory, Department of Otolaryngology - Head and Neck Surgery, Massachusetts Eye and Ear and Harvard Medical School, Boston, MA, USA.
Pavel GorelikResearch Instrumentation Core, Department of Neurobiology, Harvard Medical School, Boston, MA, USA.
Ofer MazorResearch Instrumentation Core, Department of Neurobiology, Harvard Medical School, Boston, MA, USA.
Tessa HadlockSurgical Photonics and Engineering Laboratory, Department of Otolaryngology - Head and Neck Surgery, Massachusetts Eye and Ear and Harvard Medical School, Boston, MA, USA.
Nate JowettSurgical Photonics and Engineering Laboratory, Department of Otolaryngology - Head and Neck Surgery, Massachusetts Eye and Ear and Harvard Medical School, Boston, MA, USA.
Massachusetts Eye and Ear Infirmary · USHarvard University · US

Funding

Viral ModuleP30EY012196 · NEI · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI Gabriel Kreiman · 1998 to 2026
$21.3M
Surgical and Rehabilitative Management of Facial Nerve InjuryR01NS071067 · NINDS · MASSACHUSETTS EYE AND EAR INFIRMARY · PI HADLOCK, THERESA A · 2010 to 2020
$4.6M
NEI NIH HHS P30 EY012196NINDS NIH HHS R01 NS071067
6 · The paper itself

Abstract

backgroundDisease processes causing increased neural compartment pressure may induce transient or permanent neural dysfunction. Surgical decompression can prevent and reverse such nerve damage. Owing to insufficient evidence from controlled studies, the efficacy and optimal timing of decompression surgery remains poorly characterized for several entrapment syndromes. NEW

methodWe describe the design, manufacture, and validation of a device for study of entrapment neuropathy in a small animal model. This device applies graded extrinsic pressure to a peripheral nerve and wirelessly transmits applied pressure levels in real-time. We implanted the device in rats applying low (under 100 mmHg), intermediate (200-300 mmHg) and high (above 300 mmHg) pressures to induce entrapment neuropathy of the facial nerve to mimic Bell's palsy. Facial nerve function was quantitatively assessed by tracking whisker displacements before, during, and after compression.

resultsAt low pressure, no functional loss was observed. At intermediate pressure, partial functional loss developed with return of normal function several days after decompression. High pressure demonstrated complete functional loss with incomplete recovery following decompression. Histology demonstrated uninjured, Sunderland grade III, and Sunderland grade V injury in nerves exposed to low, medium, and high pressure, respectively. COMPARISON WITH EXISTING

methodsExisting animal models of entrapment neuropathy are limited by inability to measure and titrate applied pressure over time.

conclusionsDescribed is a miniaturized, wireless, fully implantable device for study of entrapment neuropathy in a murine model, which may be broadly employed to induce various degrees of neural dysfunction and functional recovery in live animal models.

Indexed as

Disease Models, AnimalEquipment DesignAnimalsBell PalsyDecompression, SurgicalFacial NerveFemaleNerve Compression SyndromesPressureRatsBell’s PalsyBioimplantable deviceCompression neuropathyEntrapment neuropathySurgical decompression

Identifiers

PMID31626845
PMCPMC7325518
OpenAlexW2980680395

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.