ReviewNeurochemistry international2019
Developmental impact of air pollution on brain function.
Review in Neurochemistry international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
57 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Air Pollution and Brain Tumors in Children. A Systematic Review.Current environmental health reports · 2026Pooled it
- Ambient Air Pollution and Risk of Brain Tumors: A Systematic Review and Meta-Analysis.Asian Pacific journal of cancer prevention : APJCP · 2026Pooled it
- Noise, air pollution exposure and attention-deficit/hyperactivity disorder: a meta-analysis.Frontiers in psychiatry · 2026Pooled it
- Environmental pollutants as risk factors for autism spectrum disorders: a systematic review and meta-analysis of cohort studies.BMC public health · 2024Pooled it
- Prenatal Exposure to Air Pollutants and Attentional Deficit Hyperactivity Disorder Development in Children: A Systematic Review.International journal of environmental research and public health · 2023Pooled it
- Air pollution and autism-like traits: Sensitive periods and joint effects of exposure to sources and constituents of fine particulate matter.Environmental research · 2026Article
- Less air pollution previously related to clean air and climate policies is linked to improved cognitive scores over time in NYC children.Environmental health : a global access science source · 2026Article
- Neighborhood air pollution is associated with attenuated neurocognitive maturation over early adolescence.Developmental cognitive neuroscience · 2026Article
- Article
- Perinatal exposure to gaseous pollutants and autism spectrum disorder in children: A nested case-control study in the nurses' health study ii cohort.Environmental science and pollution research international · 2026Article
- Depressive symptoms mediate the associations between air pollution exposure and anemia risk: a nationwide longitudinal study in China.BMC public health · 2026Article
- Long-term air pollution exposure and gait speed decline among older Adults: A longitudinal analysis.Environmental research · 2026Article
- In utero air pollution exposure and pre- and postnatal brain development: a review.Neuroscience applied · 2026Review
- Impacts of PM2.5 Air Pollution on Migraine Outcomes in Northern Thailand: A Pilot Comparison Study of Polluted and Non-Polluted Periods.Journal of multidisciplinary healthcare · 2026Article
- Evolutionary sex bias in cognitive response to new environmental risk factor - PM2.5.Biology of sex differences · 2025Review
- Article
- Sources of outdoor air pollution exposure and child brain network development across the United States.bioRxiv : the preprint server for biology · 2025Article
- Examining the influence of musical sophistication, cognitive performance, and social skills on the Brain Age Gap Estimate (BrainAGE).Brain structure & function · 2025Article
- Key Messages of the Iodine Deficiency Working Group (AKJ): Maternal Hypothyroxinemia Due to Iodine Deficiency and Endocrine Disruptors as Risks for Child Neurocognitive Development.Geburtshilfe und Frauenheilkunde · 2025Article
- Air pollution exposures and adverse childhood experiences in relation to sleep health in middle childhood.International journal of hygiene and environmental health · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Air pollution is an important contributor to the global burden of disease, particularly to respiratory and cardiovascular diseases. In recent years, evidence is accumulating that air pollution may adversely affect the nervous system as shown by human epidemiological studies and by animal models. Age appears to play a relevant role in air pollution-induced neurotoxicity, with growing evidence suggesting that air pollution may contribute to neurodevelopmental and neurodegenerative diseases. Traffic-related air pollution (e.g. diesel exhaust) is an important contributor to urban air pollution, and fine and ultrafine particulate matter (PM) may possibly be its more relevant component. Air pollution is associated with increased oxidative stress and inflammation both in the periphery and in the nervous system, and fine and ultrafine PM can directly access the central nervous system. This short review focuses on the adverse effects of air pollution on the developing brain; it discusses some characteristics that make the developing brain more susceptible to toxic effects, and summarizes the animal and human evidence suggesting that exposure to elevated air pollution is associated with a number of behavioral and biochemical adverse effects. It also discusses more in detail the emerging evidence of an association between perinatal exposure to air pollution and increased risk of autism spectrum disorder. Some of the common mechanisms that may underlie the neurotoxicity and developmental neurotoxicity of air pollution are also discussed. Considering the evidence presented in this review, any policy and legislative effort aimed at reducing air pollution would be protective of children's well-being.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.