Evidence map›Paper›PMID 31626810›Full record

ReviewJournal of molecular biology2019

HIV-1 Replication Benefits from the RNA Epitranscriptomic Code.

Weili Kong, Efraín E Rivera-Serrano, Jason A Neidleman, Jian Zhu

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of molecular biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Article
  3. Epitranscriptomics of SARS-CoV-2 Infection.Frontiers in cell and developmental biology · 2022
    Review
  4. HibeRNAtion: HIV-1 RNA Metabolism and Viral Latency.Frontiers in cellular and infection microbiology · 2022
    Review
  5. Review
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 1 country.

Weili KongDepartment of Pathology, The Ohio State University Wexner Medical Center, Columbus, OH, 43210, USA; Gladstone Institute of Virology and Immunology, University of California, San Francisco, CA, 94158, USA. Electronic address: weili.kong@gladstone.ucsf.edu.
Efraín E Rivera-SerranoDepartment of Microbiology and Molecular Genetics, University of California, Davis, CA, 95616, USA.
Jason A NeidlemanGladstone Institute of Virology and Immunology, University of California, San Francisco, CA, 94158, USA.
Jian ZhuDepartment of Pathology, The Ohio State University Wexner Medical Center, Columbus, OH, 43210, USA. Electronic address: jian.zhu@osumc.edu.
Gladstone Institutes · USThe Ohio State University Wexner Medical Center · USUniversity of California, Davis · USUniversity of California, San Francisco · US

Funding

Investigation of Latency Promoting Genes (LPGs) in HIV Oral Reservoir CellsR01DE025447 · NIDCR · UNIVERSITY OF ROCHESTER · PI ZHU, JIAN · 2015 to 2019
$1.9M
Role of FACT Proteins in Regulating HIV Transcription and LatencyR01GM117838 · NIGMS · UNIVERSITY OF ROCHESTER · PI ZHU, JIAN · 2015 to 2018
$1.2M
Cooperation of BRD4 and TAT Associated Proteins in HIV Transcription and LatencyR33AI116180 · NIAID · UNIVERSITY OF ROCHESTER · PI ZHU, JIAN · 2016 to 2018
$1.2M
Role of FACT Proteins in Regulating HIV Transcription and LatencyR01AI150448 · NIAID · OHIO STATE UNIVERSITY · PI ZHU, JIAN · 2019 to 2019
$300k
NIAID NIH HHS R01 AI150448NIAID NIH HHS R33 AI116180NIDCR NIH HHS R01 DE025447NIGMS NIH HHS R01 GM117838
6 · The paper itself

Abstract

The effects of RNA methylation on HIV-1 replication remain largely unknown. Recent studies have discovered new insights into the effect of 2'-O-methylation and 5-methylcytidine marks on the HIV-1 RNA genome. As so far, HIV-1 benefits from diverse RNA methylations through distinct mechanisms. In this review, we summarize the recent advances in this emerging field and discuss the role of RNA methylation writers and readers in HIV-1 infection, which may help to find alternative strategies to control HIV-1 infection.

Indexed as

Epigenesis, GeneticGene Expression Regulation, ViralRNA, ViralTranscription, GeneticVirus ReplicationHIV-1HIV InfectionsHumansMethylationModels, BiologicalRNA, ViralHIV-1ReadersRNA methylationWriters

Identifiers

PMID31626810
PMCPMC6953616
OpenAlexW2980342835

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.