ArticleCell2019
Multimodal Analysis of Cell Types in a Hypothalamic Node Controlling Social Behavior.
Article in Cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 154 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
154 citing papers in PubMed.
- Rodent models of aggression: from mechanisms to clinical translation.Der Nervenarzt · 2026Review
- Whole-Brain Monosynaptic Inputs and Outputs of Corticotropin-Releasing Hormone Neurons of the Paraventricular Nucleus of the Hypothalamus in Male Mice.CNS neuroscience & therapeutics · 2026Article
- Tryptamine from wake-active monoaminergic neurons regulates sleep homeostasis.Nature neuroscience · 2026Article
- ParabrachialProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Article
- Deep Cellular and Spatial Profiling of the Mouse Spinal Cord Reveals Sex-Specific Neuron Types and the Ascending Projection Neuron Repertoire.bioRxiv : the preprint server for biology · 2026Article
- Projection-defined hypothalamic outputs differentially regulate thermogenesis and lipolysis.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- From identity to function: unveiling the cellular complexity of hypothalamic feeding circuits.Reviews in endocrine & metabolic disorders · 2026Review
- Epineuronal space: an emerging hidden hierarchy bridges neuron and mind space.Cell & bioscience · 2026Review
- Spatiotemporal analysis of autism gene enrichment implicates cortex, thalamus, and hypothalamus.bioRxiv : the preprint server for biology · 2026Article
- Article
- Spatially resolved molecular sex differences at single-cell resolution in the adult human ventromedial and arcuate hypothalamus.Cell reports · 2026Article
- A sexually dimorphic neuronal cluster in the mouse medial amygdala responds to male sexual status.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Sex-associated circadian signaling signatures in the lateral hypothalamus.Frontiers in sleep · 2026Article
- The ventrolateral preoptic nucleus: a multisystem integrator in sleep-wake regulation.Frontiers in neuroscience · 2026Review
- Functional Suppression of CLOCK Activity in Ventromedial Hypothalamic Prodynorphin Neurons Alters Locomotor Activity and Rapid Eye Movement Sleep.Neurology international · 2025Article
- A bifunctional optical reporter for tracking estrogen response dynamics in neurons.bioRxiv : the preprint server for biology · 2025Article
- Comparison of ventromedial hypothalamic nucleus growth hormone-releasing hormone neuron counterregulatory neurochemical marker gene expression in young adult versus middle-aged male and female rats.IBRO neuroscience reports · 2025Article
- A line attractor maintains aggressiveness during feeding in "hangry" mice.bioRxiv : the preprint server for biology · 2025Article
- Evolution of gene expression across brain regions in behaviourally divergent deer mice.Molecular ecology · 2025Article
94 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
19 authors.
Funding
Abstract
The ventrolateral subdivision of the ventromedial hypothalamus (VMHvl) contains ∼4,000 neurons that project to multiple targets and control innate social behaviors including aggression and mounting. However, the number of cell types in VMHvl and their relationship to connectivity and behavioral function are unknown. We performed single-cell RNA sequencing using two independent platforms-SMART-seq (∼4,500 neurons) and 10x (∼78,000 neurons)-and investigated correspondence between transcriptomic identity and axonal projections or behavioral activation, respectively. Canonical correlation analysis (CCA) identified 17 transcriptomic types (T-types), including several sexually dimorphic clusters, the majority of which were validated by seqFISH. Immediate early gene analysis identified T-types exhibiting preferential responses to intruder males versus females but only rare examples of behavior-specific activation. Unexpectedly, many VMHvl T-types comprise a mixed population of neurons with different projection target preferences. Overall our analysis revealed that, surprisingly, few VMHvl T-types exhibit a clear correspondence with behavior-specific activation and connectivity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.