Evidence map›Paper›PMID 31626395›Full record

ArticleBirth defects research2019

Circle of Willis anomalies in Turner syndrome: Absent A1 segment of the anterior cerebral artery.

Paul Kruszka, Ashley Buscetta, Maria T Acosta, Nicole Banks, Yonit A Addissie, Camilo Toro, Marie Luby, Lawrence Latour, Gilbert Vezina, David C Page and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Birth defects research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 80% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Paul KruszkaMedical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland.ORCID 0000-0003-4949-0875
Ashley BuscettaMedical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland.
Maria T AcostaMedical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland.
Nicole BanksMedical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland.
Yonit A AddissieMedical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland.
Camilo ToroUndiagnosed Disease Network, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland.
Marie LubyStroke Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland.
Lawrence LatourStroke Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland.
Gilbert VezinaThe Children's Research Institute, Children's National Health System, Washington, DC.
David C PageWhitehead Institute, Cambridge, Massachusetts.
Maximilian MuenkeMedical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland.
National Institutes of Health · USChildren's National · USHoward Hughes Medical Institute · US

Funding

CLINICAL, IMAGING, AND EXPERIMENTAL CORE SUPPORT OF ACUTE STROKE RESEARCHZIANS003044 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI LATOUR, LAWRENCE · 2009 to 2014
$24.9M
Research_ProjectU54HD090257 · NICHD · CHILDREN'S RESEARCH INSTITUTE · PI GUAY-WOODFORD, LISA MARIE · 2016 to 2020
$5.9M
Intramural NIH HHS ZIA NS003044NICHD NIH HHS U54 HD090257
6 · The paper itself

Abstract

purposeTurner syndrome (TS) is the most common sex chromosome disorder in women and is associated with a higher than expected death rate secondary to cerebrovascular disease, including stroke. This study evaluates the cerebral vascular anatomy of individuals with TS.

methodsTwenty-one women with TS had brain magnetic resonance angiography (MRA). These MRAs were evaluated in a blinded manner with a control group of 25 men and 25 women who had MRA imaging for multiple indications including migraine headaches, psychiatric disorders, and seizures.

resultsTwenty-nine percent of women with TS were missing an A1 segment of the anterior cerebral artery (ACA) compared to 0% in the control group (p < .001). There were no other significant differences in the circle of Willis (COW) in women with TS compared with the control group. A complete COW was found in 3 of 21 (14%) of women with TS and 12 of 47 (26%) controls (p = .36).

conclusionWomen with TS have a significantly different intracranial vascular anatomy, specifically the absence of the A1 segment of the ACA when compared to male and female controls. More research in brain imaging in women with TS and stroke and other cerebrovascular diseases is needed to determine the clinical significance of this anomaly.

Indexed as

AdultAnterior Cerebral ArteryBrainCircle of WillisFemaleHumansMagnetic Resonance AngiographyMaleTurner Syndromecerebrovascular diseasecircle of Willismagnetic resonance angiographymonosomy XTurner syndrome

Identifiers

PMID31626395
PMCPMC8424465
OpenAlexW2980976653

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.