Evidence map›Paper›PMID 31626329›Full record

ArticleJournal of cutaneous pathology2020

Verrucous pilar cysts infected with beta human papillomavirus.

Benjamin A Nanes, Soolmaz Laknezhad, Bahir Chamseddin, John Doorbar, Adnan Mir, Gregory A Hosler, Richard C Wang

Open access · greenAbstract readCase Reports
In one paragraph

Article in Journal of cutaneous pathology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Verrucous Cyst with Cutaneous Horn.Indian dermatology online journal
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Benjamin A NanesDepartment of Dermatology, UT Southwestern Medical Center, Dallas, Texas.ORCID https://orcid.org/0000-0001-9686-1611
Soolmaz LaknezhadDepartment of Dermatology, UT Southwestern Medical Center, Dallas, Texas.
Bahir ChamseddinDepartment of Dermatology, UT Southwestern Medical Center, Dallas, Texas.ORCID https://orcid.org/0000-0002-5729-3532
John DoorbarDepartment of Pathology, University of Cambridge, UK.
Adnan MirDermpath Diagnostics, Port Chester, New York.
Gregory A HoslerDepartment of Dermatology, UT Southwestern Medical Center, Dallas, Texas.ORCID https://orcid.org/0000-0002-6281-0565
Richard C WangDepartment of Dermatology, UT Southwestern Medical Center, Dallas, Texas.
Southwestern Medical Center · USNew York Medical College · USUniversity of Cambridge · GB

Funding

Mechanisms of Glucose Dependence in Proliferating CellsR01AR072655 · NIAMS · UT SOUTHWESTERN MEDICAL CENTER · PI WANG, RICHARD C · 2018 to 2022
$1.7M
Dermatology Research Training ProgramT32AR065969 · NIAMS · UT SOUTHWESTERN MEDICAL CENTER · PI PONCIANO D CRUZ, Tamia Alisha Harris-Tryon · 2014 to 2026
$1.6M
Cancer Research UK 28754Medical Research Council MR/S024409/1NIAMS NIH HHS R01 AR072655NIAMS NIH HHS T32 AR065969NIH HHS
6 · The paper itself

Abstract

Epidermoid cysts with histopathologic features of human papillomavirus (HPV) infection have been previously reported and are commonly termed verrucous cysts. We report a series of eight histopathologically distinct verrucous pilar cysts, distinguished from traditional verrucous epidermoid cysts by trichilemmal keratinization, as well as two verrucous hybrid pilar-epidermoid cysts. These lesions contain characteristic stratified epithelial linings with abrupt transitions to compact eosinophilic keratin, as well as areas of papillomatosis, coarse intracytoplasmic keratohyalin granules, and vacuolar structures suggestive of HPV-induced cytopathic change. HPV-24, a β genus HPV species, was identified by degenerate polymerase chain reaction in DNA extracted from two of the lesions, and the presence of β-HPV E4 protein was confirmed by immunohistochemistry. HPV-60, the HPV species most commonly reported in verrucous epidermoid cysts, was not detected. Verrucous pilar cysts represent histopathologically and potentially etiologically distinct lesions which may be underrecognized.

Indexed as

Epidermal CystPapillomavirus InfectionsSkin Diseases, ViralAdultAgedFemaleHumansMaleMiddle AgedOncogene Proteins, ViralPapillomaviridaeOncogene Proteins, ViralcystHPVhuman papillomaviruspilar cystverrucous cyst

Identifiers

PMID31626329
PMCPMC7386817
OpenAlexW2981193099

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.