ArticleThe Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology2019
Determination of the changes on the small intestine of pregnant mice by histological, enzyme histochemical, and immunohistochemical methods.
Article in The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Differential changes in anatomical, molecular and functional determinants of intestinal glucose absorption during murine pregnancy.Physiological reports · 2025Article
- A comprehensive assessment of smokeless tobacco (Shammah) extract: unraveling the effects on hematological parameters, antioxidant defense mechanisms, and organ health in rats.Journal of molecular histology · 2025Article
- Melatonin may protect the gastrointestinal system from cadmium chloride toxicity during pregnancy.Toxicology research · 2025Article
- Shenlian Decoction Ameliorates LPS-Related Inflammation in db/db Mice: Coupling Network Pharmacology With Experimental Verification.Journal of diabetes research · 2025Article
- Article
- Comparison of the effect of Sunset yellow on the stomach and small intestine of developmental period of mice.Heliyon · 2024Article
- Determination of the effects of sunset yellow on mouse liver and pancreas using histological methods.Toxicology research · 2024Article
- Determination of the Effects of Ankaferd Wound Dressing on the Wound Healing Process in Rats.Turkish journal of pharmaceutical sciences · 2024Article
- Standardization and quality assessment for human intestinal organoids.Frontiers in cell and developmental biology · 2024Article
- Standard: Human intestinal organoids.Cell regeneration (London, England) · 2023Article
- Environmental enteric dysfunction: gut and microbiota adaptation in pregnancy and infancy.Nature reviews. Gastroenterology & hepatology · 2023Review
- Maternal Antibiotic Treatment Disrupts the Intestinal Microbiota and Intestinal Development in Neonatal Mice.Frontiers in microbiology · 2021Article
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Abstract
BACKGROUND/
aimsThe aim of the present study was to determine the changes on the small intestine in mice during pregnancy using histological, enzyme histochemical, and immunohistochemical methods. MATERIALS AND
methodsA total of 24 Swiss albino female mice were divided as non-pregnant/control, first week, second week, and third week of pregnancy (n=6). Tissue samples obtained from the duodenum, jejunum, and ileum were processed by means of routine histological techniques and stained with Crossmon's triple staining. Alkaline phosphatase (ALP) was demonstrated with the simultaneous azo-coupling method. Proliferating cell nuclear antigen (PCNA) was demonstrated with the streptavidin-biotin-peroxidase complex method. The numerical data of the parameters were obtained and analyzed statistically.
resultsVillus height, villus width, and the rate of villus height/crypt depth were decreased in the duodenum, jejunum, and ileum in the last week of pregnancy compared with the control group. Changes in the crypt depth of the duodenum, jejunum, and ileum in pregnancy were found. The muscle width increased in pregnancy. It was identified that the ALP reactivity statistically significantly increased in the duodenum, jejunum, and ileum in pregnancy. The percentage of PCNA-positive cells in the duodenum, jejunum, and ileum increased in the first and second weeks of pregnancy, whereas it decreased in the third week of pregnancy compared with non-pregnant control animals.
conclusionIn conclusion, villus parameters, ALP reactivity, and percentage of PCNA-positive cells in the small intestine were affected during pregnancy.
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