Evidence map›Paper›PMID 31625931›Full record

ArticleThe Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology2019

Investigation of JAM-A (rs790056) and LFA-1 (rs8058823) gene variants in Turkish colorectal cancer patients.

Burcu Çaykara, Hani Alsaadoni, Halime Hanım Pençe, Sadrettin Pençe, Hülya Yılmaz Aydoğan, Didem Taştekin

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Burcu ÇaykaraDepartment of Physiology, İstanbul Medeniyet University School of Medicine, İstanbul, Turkey.
Hani AlsaadoniDepartment of Molecular Medicine, İstanbul University Aziz Sancar Institute of Experimental Medicine (ASDETAE), İstanbul, Turkey.
Halime Hanım PençeDepartment of Medical Biochemistry, University of Health Sciences School of Medicine, İstanbul, Turkey.
Sadrettin PençeDepartment of Physiology, University of Health Sciences School of Medicine, İstanbul, Turkey.
Hülya Yılmaz AydoğanDepartment of Molecular Medicine, İstanbul University Aziz Sancar Institute of Experimental Medicine (ASDETAE), İstanbul, Turkey.
Didem TaştekinDepartment of Clinical Oncology, İstanbul University Institute of Oncology, İstanbul, Turkey.
Istanbul University · TRSağlık Bilimleri Üniversitesi · TRIstanbul Medeniyet University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimsLymphocyte function-associated antigen 1 (LFA-1) is a transmembrane glycoprotein expressed on the surface of leukocytes and containing the binding domain for junctional adhesion molecule-A (JAM-A). The aim of the present study was to evaluate the effects of JAM-A and LFA-1 variants on the formation of colorectal cancer and metastasis. MATERIALS AND

methodsA total of 82 subjects with colorectal cancer and 67 healthy subjects were studied. DNA was isolated from blood samples, and variations were determined using the polymerase chain reaction and restriction fragment length polymorphism method.

resultsJAM-A rs790056 CC genotype and C allele were found to be higher in the colorectal cancer group (p<0.05), and approximately 3-fold increased colorectal cancer risk with CC genotype was determined (p=0.029). Haplotype analysis showed that GC haplotype (LFA-1 rs8058823G and JAM-A rs790056C) frequency was significantly higher in the patient group (p=0.041) than in controls.

conclusionJAM-A rs790056 variation may be effective in the development of colorectal cancer.

Indexed as

AdultAgedAllelesCase-Control StudiesCell Adhesion MoleculesColorectal NeoplasmsFemaleGenetic Predisposition to DiseaseGenotypeHaplotypesHumansLymphocyte Function-Associated Antigen-1MaleMiddle AgedPolymorphism, Restriction Fragment LengthReceptors, Cell SurfaceCell Adhesion MoleculesF11R protein, humanLymphocyte Function-Associated Antigen-1Receptors, Cell Surface

Identifiers

PMID31625931
PMCPMC6812956
OpenAlexW2980393219

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.