Evidence map›Paper›PMID 31625688›Full record

ArticleInfluenza and other respiratory viruses2020

Estimates for quality of life loss due to Respiratory Syncytial Virus.

David Hodgson, Katherine E Atkins, Marc Baguelin, Jasmina Panovska-Griffiths, Dominic Thorrington, Albert Jan van Hoek, Hongxin Zhao, Ellen Fragaszy, Andrew C Hayward, Richard Pebody

Abstract read
In one paragraph

Article in Influenza and other respiratory viruses, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

David HodgsonCentre for Mathematics, Physics and Engineering in the Life Sciences and Experimental Biology, University College London, London, UK.ORCID 0000-0002-5585-8974
Katherine E AtkinsCentre for the Mathematical Modelling of Infectious Diseases, London School of Hygiene & Tropical Medicine, London, UK.ORCID 0000-0001-5250-0558
Marc BaguelinCentre for the Mathematical Modelling of Infectious Diseases, London School of Hygiene & Tropical Medicine, London, UK.
Jasmina Panovska-GriffithsCentre for Mathematics, Physics and Engineering in the Life Sciences and Experimental Biology, University College London, London, UK.
Dominic ThorringtonCentre for the Mathematical Modelling of Infectious Diseases, London School of Hygiene & Tropical Medicine, London, UK.
Albert Jan van HoekDepartment of Infectious Disease Epidemiology, Faculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London, UK.
Hongxin ZhaoRespiratory Diseases Department, Public Health England, London, UK.
Ellen FragaszyDepartment of Infectious Disease Epidemiology, Faculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London, UK.ORCID 0000-0002-0178-6098
Andrew C HaywardDepartment of Epidemiology and Public Health, University College London, London, UK.
Richard PebodyRespiratory Diseases Department, Public Health England, London, UK.

Funding

Department of HealthMedical Research Council G0600511Medical Research Council G0800767Medical Research Council MC_U122785833
6 · The paper itself

Abstract

backgroundIn children aged <5 years in whom severe respiratory syncytial virus (RSV) episodes predominantly occur, there are currently no appropriate standardised instruments to estimate quality of life years (QALY) loss.

objectivesWe estimated the age-specific QALY loss due to RSV by developing a regression model which predicts the QALY loss without the use of standardised instruments.

methodsWe conducted a surveillance study which targeted confirmed RSV episodes in children aged <5 years (confirmed cases) and their household members who experienced symptoms of RSV during the same time (suspected cases). All participants were asked to complete questions regarding their health during the infection, with the suspected cases additionally providing health-related quality of life (HR-QoL) loss estimates by completing EQ-5D-3L-Y or EQ-5D-3L instruments. We used the responses from the suspected cases to calibrate a regression model which estimates the HR-QoL and QALY loss due to infection.

findingsFor confirmed RSV cases in children under 5 years of age who sought health care, our model predicted a QALY loss per RSV episode of 3.823 × 10

conclusionEvaluations of potential RSV vaccination programmes should consider their impact across the whole population, not just young child children.

Indexed as

Quality of LifeActivities of Daily LivingAdolescentAdultChildChild, PreschoolFemaleHumansInfantMaleRespiratory Syncytial Virus, HumanRespiratory Syncytial Virus InfectionsSeasonsYoung Adultcost-effectivenessEQ-5Dhealth-related quality of lifehuman respiratory syncytial virusquality-adjusted life yearsrespiratory disease

Identifiers

PMID31625688
PMCPMC6928035

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.