ArticleeLife2019
Independent representations of ipsilateral and contralateral limbs in primary motor cortex.
Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
44 citing papers in PubMed.
- Restoring rapid natural bimanual typing with a neuroprosthesis after paralysis.Nature neuroscience · 2026Article
- Cognitive-Motor Duality in Human M1 and Cerebellum.Research square · 2026Article
- Sparse component analysis: A method that uncovers separable computations within neural population activity.Neuron · 2026Article
- Acute Modulation of Lumbar Motor Unit Behavior During Experimentally Induced Low Back Pain: A Motor Unit Decomposition Analysis.Physiotherapy research international : the journal for researchers and clinicians in physical therapy · 2026Article
- A neural language for the cerebellum: control of behavior via competing populations of Purkinje cells.Journal of neurophysiology · 2026Review
- Brain network and activity in frontal regions change in the process of visuomotor adaptation.Scientific reports · 2025Article
- Human Applications of Transcranial Temporal Interference Stimulation: A Systematic Review.medRxiv : the preprint server for health sciences · 2025Article
- Cortical sculpting of a rhythmic motor program.bioRxiv : the preprint server for biology · 2025Article
- Cognitive independence and interactions between cerebral hemispheres.Neuropsychologia · 2025Review
- The role of the contralesional primary motor cortex in upper limb recovery after stroke: a scoping review following PRISMA-ScR guidelines.BMC neuroscience · 2025Article
- Article
- Efficacy of dual-target iTBS on gait function and brain activation in stroke patients: a randomized, single-blinded, sham-controlled study.Frontiers in neurology · 2025Article
- Comparison of contralateral muscle excitation in proximal versus distal muscles in the upper extremities.Frontiers in human neuroscience · 2025Article
- Asymmetry in contralateral muscle excitation in proximal vs. distal muscles in upper extremities.Frontiers in psychology · 2025Article
- Article
- Preparatory activity and the expansive null-space.Nature reviews. Neuroscience · 2024Review
- Identifying Interpretable Latent Factors with Sparse Component Analysis.bioRxiv : the preprint server for biology · 2024Article
- Article
- Does Ipsilateral Remapping Following Hand Loss Impact Motor Control of the Intact Hand?The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Contribution of the subthalamic nucleus to motor, cognitive and limbic processes: an electrophysiological and stimulation study in monkeys.Frontiers in neuroscience · 2024Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Several lines of research demonstrate that primary motor cortex (M1) is principally involved in controlling the contralateral side of the body. However, M1 activity has been correlated with both contralateral and ipsilateral limb movements. Why does ipsilaterally-related activity not cause contralateral motor output? To address this question, we trained monkeys to counter mechanical loads applied to their right and left limbs. We found >50% of M1 neurons had load-related activity for both limbs. Contralateral loads evoked changes in activity ~10ms sooner than ipsilateral loads. We also found corresponding population activities were distinct, with contralateral activity residing in a subspace that was orthogonal to the ipsilateral activity. Thus, neural responses for the contralateral limb can be extracted without interference from the activity for the ipsilateral limb, and vice versa. Our results show that M1 activity unrelated to downstream motor targets can be segregated from activity related to the downstream motor output.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.