ArticleACS infectious diseases2019
Intrabacterial Metabolism Obscures the Successful Prediction of an InhA Inhibitor of
Abstract read
In one paragraph
Article in ACS infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Identification of chemical features for improved outer membrane permeation in mycobacteria using machine learning.Nature microbiology · 2026Article
- Article
- The Quantification of Drug Accumulation within Gram-Negative Bacteria.ACS infectious diseases · 2026Article
- Mutations in the transcriptional regulator MAB_2885 confer tedizolid and linezolid resistance through the MmpS-MmpL efflux pump MAB_2302-MAB_2303 in Mycobacterium abscessus.PLoS pathogens · 2025Article
- Efflux pumps and membrane permeability contribute to intrinsic antibiotic resistance in Mycobacterium abscessus.PLoS pathogens · 2025Article
- Identification of chemical features that influence mycomembrane permeation and antitubercular activity.bioRxiv : the preprint server for biology · 2025Article
- A folate inhibitor exploits metabolic differences in Pseudomonas aeruginosa for narrow-spectrum targeting.Nature microbiology · 2024Article
- On the additive artificial intelligence-based discovery of nanoparticle neurodegenerative disease drug delivery systems.Beilstein journal of nanotechnology · 2024Article
- The implication of Mycobacterium tuberculosis-mediated metabolism of targeted xenobiotics.Nature reviews. Chemistry · 2023Review
- Advances in computational frameworks in the fight against TB: The way forward.Frontiers in pharmacology · 2023Review
- Discovery of New Zika Protease and Polymerase Inhibitors through the Open Science Collaboration Project OpenZika.Journal of chemical information and modeling · 2022Article
- Random Forest Model Predictions Afford Dual-Stage Antimalarial Agents.ACS infectious diseases · 2022Article
- Review
- Bayesian Modeling and Intrabacterial Drug Metabolism Applied to Drug-ResistantACS infectious diseases · 2021Article
- Targeting Mycobacterium tuberculosis response to environmental cues for the development of effective antitubercular drugs.PLoS biology · 2021Article
- Structure-basedComputational and structural biotechnology journal · 2021Review
- Machine Learning Platform to Discover Novel Growth Inhibitors of Neisseria gonorrhoeae.Pharmaceutical research · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Xin WangDepartment of Pharmacology, Physiology, and Neuroscience , Rutgers University-New Jersey Medical School , Medical Sciences Building, 185 South Orange Avenue , Newark , New Jersey 07103 , United States.
Alexander L PerrymanDepartment of Pharmacology, Physiology, and Neuroscience , Rutgers University-New Jersey Medical School , Medical Sciences Building, 185 South Orange Avenue , Newark , New Jersey 07103 , United States.
Shao-Gang LiDepartment of Pharmacology, Physiology, and Neuroscience , Rutgers University-New Jersey Medical School , Medical Sciences Building, 185 South Orange Avenue , Newark , New Jersey 07103 , United States.
Steve D PagetDepartment of Pharmacology, Physiology, and Neuroscience , Rutgers University-New Jersey Medical School , Medical Sciences Building, 185 South Orange Avenue , Newark , New Jersey 07103 , United States.
Thomas P StrattonDepartment of Pharmacology, Physiology, and Neuroscience , Rutgers University-New Jersey Medical School , Medical Sciences Building, 185 South Orange Avenue , Newark , New Jersey 07103 , United States.
Alex LemenzeDivision of Infectious Disease, Department of Medicine, and the Ruy V. Lourenço Center for the Study of Emerging and Reemerging Pathogens , Rutgers University-New Jersey Medical School , Medical Sciences Building, 185 South Orange Avenue , Newark , New Jersey 07103 , United States.
Arthur J OlsonDepartment of Integrative Structural and Computational Biology , The Scripps Research Institute , Room MB112/Mail Drop MB5, 10550 North Torrey Pines Road , La Jolla , California 92037 , United States.ORCID 0000-0003-0558-4618
Sean EkinsCollaborations in Chemistry , 5616 Hilltop Needmore Road , Fuquay-Varina , North Carolina 27526 , United States.ORCID 0000-0002-5691-5790
Pradeep KumarDivision of Infectious Disease, Department of Medicine, and the Ruy V. Lourenço Center for the Study of Emerging and Reemerging Pathogens , Rutgers University-New Jersey Medical School , Medical Sciences Building, 185 South Orange Avenue , Newark , New Jersey 07103 , United States.
Joel S FreundlichDepartment of Pharmacology, Physiology, and Neuroscience , Rutgers University-New Jersey Medical School , Medical Sciences Building, 185 South Orange Avenue , Newark , New Jersey 07103 , United States.ORCID 0000-0002-3411-3455
Funding
Biocomputation across distributed private datasets to enhance drug discoveryR44TR000942 · NCATS · COLLABORATIVE DRUG DISCOVERY, INC. · PI BUNIN, BARRY A · 2013 to 2018
$2.9MNew Drug for Treatment of Chronic Bacterial InfectionDP2OD008459 · OD · JOHNS HOPKINS UNIVERSITY · PI LAMICHHANE, GYANU · 2011 to 2013
$2.6MNCATS NIH HHS R44 TR000942NIH HHS DP2 OD008459
Abstract
Tuberculosis, caused by
Indexed as
AminesAntitubercular AgentsBacterial ProteinsBinding SitesHigh-Throughput Screening AssaysLigandsMolecular Docking SimulationMycobacterium tuberculosisNitric OxideOxadiazolesOxidoreductasesProtein ConformationAminesAntitubercular AgentsBacterial ProteinsInhA protein, MycobacteriumLigandsNitric OxideOxadiazolesOxidoreductasesBayesiandockingInhAintrabacterialmetabolismtuberculosis
Identifiers
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.