ArticleJournal of biomedical optics2019
Development of a blood oxygenation phantom for photoacoustic tomography combined with online pO2 detection and flow spectrometry.
Article in Journal of biomedical optics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 55 citations in OpenAlex.
- Volumetric photoacoustic imaging of elastin and age-related remodeling using near-infrared probe ElaNIR.Photoacoustics · 2026Article
- OpenQPAIData: Measurements of test objects with reference labels for quantitative photoacoustic imaging research.Scientific data · 2026Article
- The confounding effects of skin colour in photoacoustic imaging.Nature communications · 2026Article
- Blood-mimicking dye phantoms for evaluating photoacoustic oximetry accuracy.Photoacoustics · 2026Article
- Development of a multiparameter phantom system for multispectral imaging.Biomedical optics express · 2025Article
- Influence of the orientation of constructed blood vessels during the 3D printing on the measurement of the pseudo-oxygen saturation of an artificial blood substitute using conventional oxygen sensors: a test series.3D printing in medicine · 2024Article
- A Facile Approach to Producing Liposomal J-Aggregates of Indocyanine Green with Diagnostic and Therapeutic Potential.Advanced therapeutics · 2024Article
- In Vitro and In Vivo Anti-Inflammatory and Antidepressant-like Effects ofPlants (Basel, Switzerland) · 2024Article
- Distribution-informed and wavelength-flexible data-driven photoacoustic oximetry.Journal of biomedical optics · 2024Article
- Resonance frequency measurement to identify stiffness variations based on photoacoustic imaging.Biophysics and physicobiology · 2024Article
- Effects of skin tone on photoacoustic imaging and oximetry.Journal of biomedical optics · 2024Article
- A review of a strategic roadmapping exercise to advance clinical translation of photoacoustic imaging: From current barriers to future adoption.Photoacoustics · 2023Review
- Calibrated Photoacoustic Spectrometer Based on a Conventional Imaging System for In Vitro Characterization of Contrast Agents.Sensors (Basel, Switzerland) · 2022Article
- Functional photoacoustic microscopy of hemodynamics: a review.Biomedical engineering letters · 2022Review
- In-vivo functional and structural retinal imaging using multiwavelength photoacoustic remote sensing microscopy.Scientific reports · 2022Article
- Impact of skin tone on photoacoustic oximetry and tools to minimize bias.Biomedical optics express · 2022Article
- Transcranial photoacoustic characterization of neurovascular physiology during early-stage photothrombotic stroke in neonatal pigletsJournal of neural engineering · 2022Article
- Suite of 3D test objects for performance assessment of hybrid photoacoustic-ultrasound breast imaging systems.Journal of biomedical optics · 2021Article
- Review of consensus test methods in medical imaging and current practices in photoacoustic image quality assessment.Journal of biomedical optics · 2021Review
- In Vitro and In Vivo Multispectral Photoacoustic Imaging for the Evaluation of Chromophore Concentration.Sensors (Basel, Switzerland) · 2021Article
Corrections and comments
- Erratum issued
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Photoacoustic tomography (PAT) is intrinsically sensitive to blood oxygen saturation (sO2) in vivo. However, making accurate sO2 measurements without knowledge of tissue- and instrumentation-related correction factors is extremely challenging. We have developed a low-cost flow phantom to facilitate validation of PAT systems. The phantom is composed of a flow circuit of tubing partially embedded within a tissue-mimicking material, with independent sensors providing online monitoring of the optical absorption spectrum and partial pressure of oxygen in the tube. We first test the flow phantom using two small molecule dyes that are frequently used for photoacoustic imaging: methylene blue and indocyanine green. We then demonstrate the potential of the phantom for evaluating sO2 using chemical oxygenation and deoxygenation of blood in the circuit. Using this dynamic assessment of the photoacoustic sO2 measurement in phantoms in relation to a ground truth, we explore the influence of multispectral processing and spectral coloring on accurate assessment of sO2. Future studies could exploit this low-cost dynamic flow phantom to validate fluence correction algorithms and explore additional blood parameters such as pH and also absorptive and other properties of different fluids.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.