ArticleMolecular genetics & genomic medicine2019
The expression of human leukocyte antigen by human ejaculated spermatozoa.
Article in Molecular genetics & genomic medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 16 citations in OpenAlex.
- A Pilot Analysis of Whole Transcriptome of Human Cryopreserved Sperm.International journal of molecular sciences · 2024Article
- Solutions to the fertility equation in beef embryo recipients.Animal reproduction · 2024Review
- CD33 as a leukocyte-associated marker expressed on human spermatozoa.BMC research notes · 2023Article
- Article
- Sperm Physiological Response to Female Serum-Potential New Insights into the Reproductive Incompatibility Diagnostics.International journal of molecular sciences · 2022Article
- Spermatozoa Induce Maternal Mononuclear Cells for Production of Antibody with Cytotoxic Activity on Paternal Blood Mononuclear Cells.Cell journal · 2021Article
- Suppression of Non-Random Fertilization by MHC Class I Antigens.International journal of molecular sciences · 2020Article
- Post-copulatory genetic matchmaking: HLA-dependent effects of cervical mucus on human sperm function.Proceedings. Biological sciences · 2020Article
- KIR and HLA-C genes in male infertility.Journal of assisted reproduction and genetics · 2020Article
- The expression of human leukocyte antigen by human ejaculated spermatozoa.Molecular genetics & genomic medicine · 2019Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAfter coitus and insemination, an inflammatory response is evident in the female reproductive tract (FRT). Semen contains a variety of immune-activating components that have a major role in the induction of an immune response in the FRT. One of the most important is (human leukocyte antigen) HLA molecules which are present in soluble form in seminal plasma and in membrane form on the surface of cells (such as epithelial and leukocytes) existing in semen. Nevertheless, there is considerable debate over the expression of HLA antigens by human spermatozoa. Considering the critical role of HLA molecules in reproduction and the induction of an immune response, it is very important to clearly define HLA expression by spermatozoa and the role of these molecules in sperm morphology, motility, and strength to fertilize an egg. Therefore, the objective of this study was to determine HLA expression by ejaculated spermatozoa. The results of this study will facilitate the design of future studies.
methodSemen samples were collected from 50 healthy men with normal semen status by masturbation after 2-3 days of sexual abstinence. After purification of normal spermatozoa, HLA class I & II expression was evaluated by quantitative real-time PCR and flow cytometry methods.
resultsThe results showed the expression of both HLA class I & class II by spermatozoa. The results also showed that the expression of HLA class Ⅱ was significantly more than HLA class Ⅰ.
conclusionSpermatozoa express both HLA class I & class II molecules.
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