Evidence map›Paper›PMID 31625118›Full record

Observational studyHigh blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension2019

Prognostic Significance of Heart Rate and Beta-Blocker Use in Sinus Rhythm in Patients with Heart Failure and Preserved Ejection Fraction.

Shijun Li, Xiaoying Li

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

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0cells of the map it votes in
3citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Observational
  3. Comments About: Prognostic Significance of Heart Rate and Beta-Blocker Use in Sinus Rhythm in Patients with Heart Failure and Preserved Ejection Fraction.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2019
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Shijun LiDepartment of Geriatric Cardiology, Chinese PLA General Hospital, No. 28, Fuxing Road, Beijing, 100853, People's Republic of China. lishijun817@126.com.
Xiaoying LiDepartment of Geriatric Cardiology, Chinese PLA General Hospital, No. 28, Fuxing Road, Beijing, 100853, People's Republic of China.

Funding

National Natural Science Foundation of China 81570384
6 · The paper itself

Abstract

introductionPrognostic significance of heart rate (HR) in heart failure with preserved ejection fraction (HFpEF) remains poorly understood.

aimTo evaluate the association of HR and beta-blocker use with all-cause mortality and the optimal HR range in patients with HFpEF and sinus rhythm (SR).

methodsDuring a follow-up of 2.7 years (IQR 1.2-4.1 years), the 330 patients with median age 73 (IQR 64-79) years, 52.1% men, were included. HFpEF was defined as patients with EF ≥ 50%. The outcome measure was all-cause mortality.

resultsIn total, 96 (29.1%) of patients with HFpEF and SR died. A linear tendency between HR and mortality was observed in SR. Compared to the reference strata HR ≤ 60 bpm, HR increment was associated with progressively increased risk in mortality (Chi-square = 13.90, Log rank P = 0.001) by Kaplan-Meier analyses. Univariate Cox regression showed that in SR, compared with that in HR 61-80 bpm, the unadjusted hazard ratios for mortality were 0.41 (95% CI 0.23-0.74, P  = 0.003) in HR ≤ 60 bpm, 1.38 (95% CI 0.85-2.24, P  = 0.189) in HR > 80 bpm. Multivariate Cox regression showed that compared with that in HR 61-80 bpm, the adjusted hazard ratios for mortality were 0.37 (95% CI 0.19-0.75, P  =  0.005) in HR ≤ 60 bpm, 0.96 (95% CI 0.52-1.74, P  = 0.899) in HR > 80 bpm. Univariate Cox regression showed that the unadjusted hazard ratios for mortality were 0.52 (95% CI 0.33-0.84, P = 0.003) in patients with beta-blocker as compared patients without beta-blocker. Multivariate Cox regression showed that the adjusted hazard ratios for mortality were 0.48 (95% CI 0.26-0.87, P = 0.016) in patients with beta-blocker as compared patients without beta-blocker.

conclusionsHR is independently associated with increased all-cause mortality in SR and a lower HR (≤ 60 bpm) is favorable for better outcome in HFpEF patients with SR. Beta-blocker use is associated with reduced mortality and a lower HR is associated with reduced mortality in HFpEF patients with SR.

Indexed as

Stroke VolumeVentricular Function, LeftAdrenergic beta-AntagonistsAgedAged, 80 and overCause of DeathFemaleHeart FailureHeart RateHumansMaleMiddle AgedRisk AssessmentRisk FactorsTime FactorsTreatment OutcomeAdrenergic beta-AntagonistsBeta-blockerHeart failureHeart ratePreserved ejection fractionSinus rhythm

Identifiers

PMID31625118

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.