SynthesisJournal of cancer survivorship : research and practice2019
Social attainment in survivors of pediatric central nervous system tumors: a systematic review and meta-analysis from the Children's Oncology Group.
Synthesis in Journal of cancer survivorship : research and practice, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 4 syntheses or guidelines pooled it, 73 citations in OpenAlex.
- Social adjustment across the lifespan in survivors of pediatric acute lymphoblastic leukemia (ALL): a systematic review.Journal of cancer survivorship : research and practice · 2023Pooled it
- Umbrella systematic review finds limited evidence that school absence explains the association between chronic health conditions and lower academic attainment.Frontiers in public health · 2023Pooled it
- Diffusion tensor imaging indices as biomarkers for cognitive changes following paediatric radiotherapy: a systematic review and meta-analysis.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2022Pooled it
- Neurocognitive impairment following proton therapy for paediatric brain tumour: a systematic review of post-therapy assessments.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021Pooled it
- Attention and executive functioning in children and adolescents treated for high-risk acute lymphoblastic leukemia: A report from the Children's Oncology Group (COG).Pediatric blood & cancer · 2024Trial
- Listening to children's voices: Psychosocial and behavioral experiences and identity-related changes during the cancer trajectory.Asia-Pacific journal of oncology nursing · 2026Article
- A comparison of a novel neuropsychological screening tool with provider recommendations among pediatric cancer survivors.Journal of cancer survivorship : research and practice · 2026Article
- Bridging pediatric and adult neuro-oncology: Insights into adolescents and young adults (AYA) central nervous system tumors.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Review
- Psychosocial functioning and friendship quality among school-aged pediatric brain tumor survivors.Journal of pediatric psychology · 2026Article
- Adolescents and young adults with predominantly low grade primary central nervous system tumors: patient reported socioeconomic outcomes and health-related quality of life ten years after diagnosis.Journal of neuro-oncology · 2026Article
- Social information processing in survivors of pediatric brain tumors.Journal of cancer survivorship : research and practice · 2026Article
- Article
- Neighborhood resources are associated with neuropsychological outcomes among pediatric brain tumor survivors.The Clinical neuropsychologist · 2025Article
- Motor and sensory impairment in survivors of childhood central nervous system (CNS) tumors in the St. Jude Lifetime Cohort (SJLIFE).Cancer medicine · 2024Article
- Identifying social outcomes of importance for childhood cancer survivors: an e-Delphi study.Journal of patient-reported outcomes · 2024Review
- Cancer-related stress in childhood cancer survivorship: Prevalence and associations with perceptions of health risks and quality of life.Psycho-oncology · 2024Article
- Caregivers matter: Neurological vulnerability for pediatric brain tumor survivors.Neuro-oncology practice · 2023Article
- Social cognition and adjustment in adult survivors of pediatric central nervous system tumors.Cancer · 2023Article
- Children's Oncology Group's 2023 blueprint for research: Behavioral science.Pediatric blood & cancer · 2023Article
- Income disparities between adult childhood cancer survivors and their peers-A register-based cohort study from the SALiCCS research programme.Cancer medicine · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 8 institutions in 2 countries.
Funding
Abstract
purposeImproved therapies for pediatric central nervous system (CNS) tumors have increased survival rates; however, many survivors experience significant long-term functional limitations. Survivors of pediatric CNS tumors can experience deficits in social attainment. The aim of this review was to systematically amalgamate findings pertaining to social attainment (i.e., educational attainment, marriage, employment outcomes) in survivors of pediatric CNS tumors.
methodsPubMed (web-based), PsycINFO (EBSCO), EMBASE (Ovid), and Web of Science (Thomson Reuters) were used to identify articles published between January 2011 and September 2018. Eligible studies reported outcomes for survivors of pediatric CNS tumors diagnosed before age 21 years and > 5 years from diagnosis and/or > 2 years off therapy. All data were independently abstracted by two reviewers. Random-effects meta-analyses were performed using Review Manager 5.0.
resultsThe search yielded 7021 unique publications. Forty-six were included in the current review. Meta-analyses revealed survivors of CNS tumors were significantly more likely to have completed compulsory education only (OR = 1.87, 95% CI = 1.66, 2.12, p < 0.00001), less likely to be married (OR = 4.70, 95% CI = 3.89, 5.68, p < 0.00001), and more likely to be unemployed (OR = 2.84, 95% CI = 2.62, 3.08, p < 0.00001) compared to non-cancer controls. Cranial radiation therapy, neurocognitive deficits, and younger age at diagnosis were associated with poorer outcomes. Hearing loss and bilateral blindness were also related to poorer outcomes. Sex did not impact social attainment outcomes.
conclusionsSurvivors of pediatric CNS tumors are at elevated risk for poor attainment of key adult social outcomes. IMPLICATIONS FOR CANCER SURVIVORS: There is a critical need to develop interventions to support survivors in becoming independent and productive adults.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.