Evidence map›Paper›PMID 31625007›Full record

ArticleClinical and experimental medicine2020

The epithelial cadherin -160C/A polymorphism is associated with decreased risk of colorectal cancer: a case-control study.

Wenhuan Li, Deshuang Xiao, Huawen Wu, Lewei Xu

Abstract read
PubMed Publisher
In one paragraph

Article in Clinical and experimental medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Wenhuan Li *Department of Gastrointestinal Surgery, The Affliated Wenling Hospital of Wenzhou Medical University, The First People's Hospital of Wenling, No. 333 Chuan'an South Road, Chengxi Street, Wenling, Taizhou, China.
Deshuang Xiao *Department of Liver and Gallbladder Surgery, The Affliated Wenling Hospital of Wenzhou Medical University, The First People's Hospital of Wenling, No. 333 Chuan'an South Road, Chengxi Street, Wenling, Taizhou, China.
Huawen WuDepartment of Gastrointestinal Surgery, The Affliated Wenling Hospital of Wenzhou Medical University, The First People's Hospital of Wenling, No. 333 Chuan'an South Road, Chengxi Street, Wenling, Taizhou, China.
Lewei XuDepartment of Surgery, The Affliated Wenling Hospital of Wenzhou Medical University, The First People's Hospital of Wenling, No. 333 Chuan'an South Road, Chengxi Street, Wenling, Taizhou, China. xlw220518@163.com.ORCID http://orcid.org/0000-0002-5190-1111
Wenzhou Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The epithelial cadherin (CDH1) is an important determinant of tumor progression. Previous studies have indicated that the CDH1 -160C/A polymorphism was associated with the risk of colorectal cancer (CRC). However, they yielded conflicting results. Thus, we conducted this case-control study to evaluate the association between the CDH1 -160C/A polymorphism and susceptibility to CRC in a Chinese population. We recruited 351 cases and 411 controls in this case-control study. The genotype of the CDH1 -160C/A polymorphism was performed by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOFMS). This study found that the CDH1 -160C/A polymorphism was associated with decreased risk of CRC in this Chinese Han population. Subgroup analyses showed that the CDH1 -160C/A polymorphism decreased the risk of CRC among the males and non-drinkers. In addition, a significantly decreased risk was observed in CRC patients with tumor size ≤ 5 cm, and AA genotype showed a protective role in the CRC patients with no lymph node metastasis. In conclusion, this study shows that CDH1 -160C/A polymorphism is associated with decreased risk of CRC in a Chinese Han population.

Indexed as

Polymorphism, Single NucleotideAdultAgedAged, 80 and overAlcohol DrinkingAntigens, CDCadherinsCase-Control StudiesChinaColorectal NeoplasmsFemaleGenetic Association StudiesGenetic Predisposition to DiseaseHumansMaleMiddle AgedAntigens, CDCadherinsCDH1 protein, humanCase–control studyColorectal cancerEpithelial cadherinPolymorphism

Identifiers

PMID31625007
OpenAlexW2981164826

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.