Evidence map›Paper›PMID 31624899›Full record

ArticleArchives of dermatological research2020

TYRP1 mRNA level is stable and MITF-M-independent in drug-naïve, vemurafenib- and trametinib-resistant BRAF

Mariusz L Hartman, Malgorzata Czyz

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Archives of dermatological research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Visual input regulates melanophore differentiation.Frontiers in cell and developmental biology · 2024
    Article
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Mariusz L HartmanDepartment of Molecular Biology of Cancer, Medical University of Lodz, 6/8 Mazowiecka Street, 92-215, Lodz, Poland.
Malgorzata CzyzDepartment of Molecular Biology of Cancer, Medical University of Lodz, 6/8 Mazowiecka Street, 92-215, Lodz, Poland. malgorzata.czyz@umed.lodz.pl.ORCID http://orcid.org/0000-0002-8279-4742
Medical University of Lodz · PL

Funding

National Science Centre 2014/15/B/NZ7/00947
6 · The paper itself

Abstract

TYRP1 mRNA is of interest due to its potential non-coding role as a sponge sequestering tumor-suppressive miRs in melanoma. To our knowledge, there is no report on changes in TYRP1 expression in melanomas after development of resistance to targeted therapies. We used patient-derived drug-naïve RAS

Indexed as

Cell Line, TumorDrug Resistance, NeoplasmGene Expression Regulation, NeoplasticHumansMelanomaMembrane GlycoproteinsMicrophthalmia-Associated Transcription FactorMutationNeoplasm Recurrence, LocalOxidoreductasesProtein IsoformsProto-Oncogene Proteins B-rafPyridonesPyrimidinonesRNA, MessengerSkin NeoplasmsBRAF protein, humanMembrane GlycoproteinsMicrophthalmia-Associated Transcription FactorMITF protein, humanOxidoreductasesProtein IsoformsProto-Oncogene Proteins B-rafPyridonesPyrimidinonesRNA, MessengertrametinibTYRP1 protein, humanVemurafenibMelanomamiR spongeMITFResistanceTargeted therapyTYRP1

Identifiers

PMID31624899
PMCPMC7248034
OpenAlexW2980626490

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.