Evidence map›Paper›PMID 31624870›Full record

ArticleActa neuropathologica2019

Production of poly(GA) in C9ORF72 patient motor neurons derived from induced pluripotent stem cells.

Sandra Almeida, Gopinath Krishnan, Mia Rushe, Yuanzheng Gu, Mark W Kankel, Fen-Biao Gao

Abstract readLetter
In one paragraph

Article in Acta neuropathologica, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Article
  2. Article
  3. Cryptic intronic transcriptional initiation generates efficient endogenous mRNA templates for C9orf72-associated RAN translation.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Comprehensive evaluation of human-derived anti-poly-GA antibodies in cellular and animal models ofProceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  11. Article
  12. Article
  13. Review
  14. The progress inSmall GTPases · 2022
    Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sandra AlmeidaDepartment of Neurology, University of Massachusetts Medical School, Worcester, MA, 01605, USA. sandra.almeida@umassmed.edu.
Gopinath KrishnanDepartment of Neurology, University of Massachusetts Medical School, Worcester, MA, 01605, USA.
Mia RusheNeuromuscular and Movement Disorders, Biogen, Cambridge, MA, 02142, USA.
Yuanzheng GuNeuromuscular and Movement Disorders, Biogen, Cambridge, MA, 02142, USA.
Mark W KankelNeuromuscular and Movement Disorders, Biogen, Cambridge, MA, 02142, USA.
Fen-Biao GaoDepartment of Neurology, University of Massachusetts Medical School, Worcester, MA, 01605, USA. fen-biao.gao@umassmed.edu.ORCID 0000-0001-8873-5404

Funding

Investigating Pathogenic Mechanisms of Frontotemporal Dementia Caused by Mutations in CHMP2B and TBK1R37NS057553 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI GAO, FEN-BIAO · 2018 to 2024
$4.3M
Understanding Frontotemporal Dementia Using Drosophila and iPSC ModelsR01NS101986 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Fen-Biao Gao · 2017 to 2026
$3.6M
Prefrontal AMPA receptors in FTD PathogenesisR01NS093097 · NINDS · UPSTATE MEDICAL UNIVERSITY · PI GAO, FEN-BIAO, YAO, WEI-DONG · 2016 to 2020
$2.4M
Understanding Frontotemporal Dementia Using Drosophila and iPSC ModelsRF1NS101986 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI GAO, FEN-BIAO · 2022 to 2022
$2.1M
Investigating Translational De-repression as a Mechanism to Increase Progranulin Levels in iPSC-derived Patient NeuronsR21NS112766 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI ALMEIDA, SANDRA · 2019 to 2019
$461k
NINDS NIH HHS R01 NS093097NINDS NIH HHS R21 NS112766NINDS NIH HHS R37 NS057553NINDS NIH HHS RF1 NS101986
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

BrainC9orf72 ProteinCell LineCells, CulturedCRISPR-Cas SystemsDNA-Binding ProteinsHSP70 Heat-Shock ProteinsHumansInduced Pluripotent Stem CellsIntronsMotor NeuronsNeurogenesisProteinsRNA, MessengerSequence DeletionC9orf72 ProteinC9orf72 protein, humanDNA-Binding ProteinsHSP70 Heat-Shock ProteinsHSPA1B protein, humanpoly(glycyl-alanyl)ProteinsRNA, MessengerTARDBP protein, human

Identifiers

PMID31624870
PMCPMC6851345

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.