ArticleResearch and practice in thrombosis and haemostasis2019
Prolonged APTT of unknown etiology: A systematic evaluation of causes and laboratory resource use in an outpatient hemostasis academic unit.
Article in Research and practice in thrombosis and haemostasis, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Guidelines for Minimizing Bleeding Risk During Bronchoscopic Procedures.Advances in respiratory medicine · 2026Guideline
- Coagulation abnormalities in Dengue fever infection: A systematic review and meta-analysis.PLoS neglected tropical diseases · 2021Pooled it
- How I Investigate Borderline Prolonged aPTT: An Integrated Laboratory Approach to Mixing Studies and Factor Analysis.International journal of laboratory hematology · 2026Review
- Postpartum spontaneous hepatic bleeding in a dog.The Canadian veterinary journal = La revue veterinaire canadienne · 2025Article
- Deep learning model for screening causes of activated partial thromboplastin time prolongation using clot waveform analysis at multiple wavelengths.Scientific reports · 2025Article
- Acute Metabolic Effects in Brazilian A-29 Fighter Pilots by NMR-Based Metabolomics.Journal of proteome research · 2025Article
- Efficacy and safety of a novel multivalent mRNA vaccine against SARS-CoV-2 in experimental animals.Scientific reports · 2025Article
- Quantifying Thrombogenicity: A Bioanalytical Protocol for the Absorbance-Based Assessment of Vascular Implants with Plasma.Bio-protocol · 2025Article
- Article
- Machine learning-based prediction of postoperative mortality risk after abdominal surgery.World journal of gastrointestinal surgery · 2025Article
- Tissue plasminogen activator modified thromboelastography identifies fibrinolysis resistance in dogs with immune-mediated hemolytic anemia.Frontiers in veterinary science · 2025Article
- A retrospective study of the prevalence of isolated prolongation of activated partial thromboplastin time in the preoperative setting.JA clinical reports · 2024Article
- Rare Prekallikrein Deficiency Identified During Workup of Isolated Prolonged Activated Partial Thromboplastin Time.Ochsner journal · 2024Article
- Patient with lupus anticoagulant caused aPTT prolongation corrected with prednisolone treatment and later anticoagulation treatment due to chronic atrial fibrillation.Clinical case reports · 2023Article
- Coagulation Parameters in Post-Covid-19 Condition in Relation to Various Titers of Anti-SARS-CoV-2 IgG in Blood Plasma.International journal of general medicine · 2023Article
- The Spot Sign and Intraventricular Hemorrhage are Associated with Baseline Coagulopathy and Outcome in Intracerebral Hemorrhage.Neurocritical care · 2022Article
- A Recurrent Neural Network Model for Predicting Activated Partial Thromboplastin Time After Treatment With Heparin: Retrospective Study.JMIR medical informatics · 2022Article
- Renal pseudoaneurysm after rigid ureteroscopic lithotripsy: A case report.World journal of clinical cases · 2022Article
- Bleeding After Central Venous Catheter Placement in a Patient With Undiagnosed Acquired Hemophilia A: A Case Report.Cureus · 2022Article
- Acquired Haemophilia A: A Review of What We Know.Journal of blood medicine · 2022Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA prolonged activated partial thromboplastin time (APTT) of unknown cause is one of the most frequent reasons why outpatients are referred for hemostasis consultation. Nevertheless, very few data are available on the relative contribution of individual causes of this common clinical scenario. Here, we present a systematic evaluation of all causes of APTT prolongation in a consecutive population of outpatients referred for specialized hemostasis consultation during a 14-year period.
methodsAll cases referred to an academic specialized hemostasis outpatient unit due to APTT prolongation of unknown etiology whose prolonged APTT was confirmed in the first visit were included in the study. Data were obtained from the electronic medical records.
resultsAmong 187 consecutive patients, the most frequent causes were antiphospholipid antibodies in 22.6%, contact pathway factor deficiencies in 17.4%, other coagulation factor deficiencies in 11.6%, and vitamin K deficiency/liver disease in 11.6%. A definite cause was not identified in 22.1% of patients. Presence of antiphospholipid antibodies, and absence of bleeding symptoms were both associated with significantly longer APTT values compared to other categories/clinical scenarios. The investigation of each case required a mean of 18.2 additional tests per patient, with estimated costs ranging from US$191.60 to US$1055.60.
conclusionsOur results describe the main causes of APTT prolongation in outpatients, as well as estimates of resource use required to investigate this condition, thus providing evidence supporting the importance of measures to minimize the indiscriminate use of this assay.
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