ReviewAnnals of translational medicine2019
The use of tranexamic acid in spine surgery.
Review in Annals of translational medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06587620 (Tranexamic Acid Versus Dexmedetomidine for Improving Surgical Field Quality During Spine Surgeries), which is not on this map. Cited by 29 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Tranexamic Acid Versus Dexmedetomidine for Improving Surgical Field Quality During Spine Surgeries
Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Tranexamic acid dosage for spinal surgery: a meta-analysis.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2022Pooled it
- Comparison of Intravenous versus Topical Tranexamic Acid in Nondeformity Spine Surgery: A Meta-Analysis.BioMed research international · 2020Pooled it
- Surgical bleeding in patients undergoing posterior lumbar inter-body fusion surgery: a randomized clinical trial evaluating the effect of two mechanical ventilation mode types.European journal of medical research · 2023Trial
- The efficacy and safety of intravenous tranexamic acid in patients with posterior operation of multilevel thoracic spine stenosis: a prospective randomized controlled trial.BMC musculoskeletal disorders · 2022Trial
- ERAS Protocol Elements and Neurosurgery-Specific Considerations: A Narrative Review.Turkish journal of anaesthesiology and reanimation · 2026Article
- What clusters exist among the health care personnel screened for upper extremity musculoskeletal conditions?BMC musculoskeletal disorders · 2026Article
- Preoperative Local Infiltration of Tranexamic Acid in Posterior Lumbar Fusion: A Prospective Controlled Study.Cureus · 2026Article
- Tranexamic acid induced seizure during spine surgery: A case report.International journal of surgery case reports · 2025Article
- Safety in Spine Surgery: Risk Factors for Intraoperative Blood Loss and Management Strategies.Life (Basel, Switzerland) · 2025Review
- Use of tranexamic acid in trauma surgical specialties: a narrative review.World journal of emergency surgery : WJES · 2025Review
- Blood Management and Conservation During Adult Spine Deformity Surgery.Global spine journal · 2025Article
- Safety and efficacy of tranexamic acid in oncologic surgery for spinal metastases: A systematic review.North American Spine Society journal · 2025Review
- Article
- Application and research progress of tranexamic acid in the perioperative period of posterior lumbar interbody fusion.Frontiers in medicine · 2025Review
- Association of single bolus versus bolus followed by infusion of tranexamic acid with blood loss in adolescent idiopathic scoliosis surgery.Perioperative medicine (London, England) · 2024Article
- The Impact of Tranexamic Acid on Blood Loss Management in Primary Total Knee Arthroplasty: A Comprehensive Review.Cureus · 2024Review
- Safety of tranexamic acid in surgically treated isolated spine trauma.World journal of orthopedics · 2024Article
- Ponte Osteotomies in the Surgical Treatment of Adolescent Idiopathic Scoliosis: A Systematic Review of the Literature and Meta-Analysis of Comparative Studies.Children (Basel, Switzerland) · 2024Review
- Omission of tranexamic acid does not increase the amount of perioperative blood transfusions in patients undergoing one-level spinal fusion surgery: a retrospective propensity score-matched noninferiority study.Archives of orthopaedic and trauma surgery · 2023Article
- Editorial: Optimization of spine surgery outcomes in the pre-, peri-, and postoperative settings.Frontiers in surgery · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Patients undergoing surgical procedures of the spine with associated large volume blood loss often require perioperative blood conservation strategies. Synthetic antifibrinolytic medications such as tranexamic acid (TXA) may reduce blood transfusion requirements and postoperative complications following spinal procedures. Studies investigating the role of TXA in spine surgery have presented promising results and have proven its safety and efficacy. However, further investigation is needed to determine the optimal dosing regimen of TXA. In this article, we provide an overview of the basic science and pharmacology of TXA. A comprehensive summary of the findings from clinical trials and a review of the literature that demonstrate the risks and benefits of TXA in spine surgery are also presented.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.