ArticleNature communications2019
Histone H3K23-specific acetylation by MORF is coupled to H3K14 acylation.
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Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.
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70 citing papers in PubMed, 101 citations in OpenAlex.
- A cross-species post-translational modification profiling of histones by LC-MS/MS revealed conserved oxidative modifications in plants.The New phytologist · 2026Article
- Stage-Specific H3K14 and H3K23 Succinylation Orchestrates Insect Metamorphosis and Oogenesis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Distinct roles of the JADE and BRPF scaffolding subunits of the acetyltransferase HBO1 complex.Nature communications · 2026Article
- Coming to light: the transcriptional regulatory roles of histone lysine crotonylation in health and disease.Cellular & molecular biology letters · 2026Review
- Histone modification cross-talk: analytical tools and molecular mechanisms.The Biochemical journal · 2026Review
- CRM-TI: an enhanced pipeline for computationally assigning the target genes of cis-regulatory modules by considering comprehensive long-range regulation mechanisms.BioData mining · 2026Article
- Unraveling the complexity of the histone code: implications for gene regulation and disease.Genome biology · 2026Review
- OverlappING and DivergING roles of ING4 and ING5 in cancer, differentiation and development.Frontiers in cell and developmental biology · 2026Review
- Mass spectrometry-based profiling of single-cell histone post-translational modifications to dissect chromatin heterogeneity.Nature communications · 2025Article
- Lysine Acetyltransferase 6 in Health and Disease.MedComm · 2025Review
- Chromatin Regulatory Targets for Anticancer Therapeutics.Chemical reviews · 2025Review
- KAT6A and KAT7 Histone Acetyltransferase Complexes Are Molecular Dependencies and Therapeutic Targets in NUP98-Rearranged Acute Myeloid Leukemia.Cancer discovery · 2025Article
- KAT6A chimeras form a self-reinforcing epigenetic module with NURF and MLL/COMPASS to sustain AML.Genome biology · 2025Article
- TRIM24 directs replicative stress responses to maintain ALT telomeres via chromatin signaling.Molecular cell · 2025Article
- YEATS2: a novel cancer epigenetic reader and potential therapeutic target.Cancer cell international · 2025Review
- A multivalent engagement of ENL with MOZ.Nature structural & molecular biology · 2025Article
- Article
- A narrative review of epigenetic marker in H3K27ac and its emerging potential as a therapeutic target in cancer.Epigenomics · 2025Review
- KAT6B overexpression rescues embryonic lethality in homozygous null KAT6A mice restoring vitality and normal lifespan.Nature communications · 2025Article
- KAT6B is required for histone 3 lysine 9 acetylation and SOX gene expression in the developing brain.Life science alliance · 2025Article
10 more citing papers are in PubMed but not listed here.
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Authors and funding
24 authors at 12 institutions in 4 countries.
Brianna J KleinDepartment of Pharmacology, University of Colorado School of Medicine, Aurora, CO, 80045, USA.
Suk Min JangLaval University Cancer Research Center, CHU de Québec-UL Research Center-Oncology Division, Quebec City, QC, G1R 3S3, Canada.
Catherine LachanceLaval University Cancer Research Center, CHU de Québec-UL Research Center-Oncology Division, Quebec City, QC, G1R 3S3, Canada.
Wenyi MiCenter for Epigenetics, Van Andel Research Institute, Grand Rapids, MI, 49503, USA.
Jie LyuDepartment of Biological Chemistry, University of California, Irvine, Irvine, CA, 92697, USA.ORCID http://orcid.org/0000-0002-6530-5257
Shun SakurabaMolecular Modeling and Simulation Group, National Institute for Quantum Life Science, National Institutes for Quantum and Radiological Science and Technology, Kizugawa, Kyoto, 619 0215, Japan.ORCID http://orcid.org/0000-0001-5768-2389
Krzysztof KrajewskiDepartment of Biochemistry & Biophysics, The University of North Carolina School of Medicine, Chapel Hill, NC, 27599, USA.
Wesley W WangDepartment of Chemistry, Texas A&M University, College Station, TX, 77843, USA.
Simone SidoliEpigenetics Program, Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.ORCID http://orcid.org/0000-0001-9073-6641
Jiuyang LiuDepartment of Pharmacology, University of Colorado School of Medicine, Aurora, CO, 80045, USA.
Yi ZhangDepartment of Pharmacology, University of Colorado School of Medicine, Aurora, CO, 80045, USA.ORCID http://orcid.org/0000-0001-8170-9983
Xiaolu WangCenter for Epigenetics, Van Andel Research Institute, Grand Rapids, MI, 49503, USA.
Becka M WarfieldDepartment of Pharmacology, University of Colorado School of Medicine, Aurora, CO, 80045, USA.
Andrew J KuehThe Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3050, Australia.
Anne K VossThe Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3050, Australia.
Tim ThomasThe Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3050, Australia.
Benjamin A GarciaEpigenetics Program, Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Wenshe R LiuDepartment of Chemistry, Texas A&M University, College Station, TX, 77843, USA.ORCID http://orcid.org/0000-0002-7078-6534
Brian D StrahlDepartment of Biochemistry & Biophysics, The University of North Carolina School of Medicine, Chapel Hill, NC, 27599, USA.ORCID http://orcid.org/0000-0002-4947-6259
Hidetoshi KonoMolecular Modeling and Simulation Group, National Institute for Quantum Life Science, National Institutes for Quantum and Radiological Science and Technology, Kizugawa, Kyoto, 619 0215, Japan.ORCID http://orcid.org/0000-0001-5729-8707
Wei LiDepartment of Biological Chemistry, University of California, Irvine, Irvine, CA, 92697, USA.ORCID http://orcid.org/0000-0001-9931-5990
Xiaobing ShiCenter for Epigenetics, Van Andel Research Institute, Grand Rapids, MI, 49503, USA.ORCID http://orcid.org/0000-0001-5242-8189
Jacques CôtéLaval University Cancer Research Center, CHU de Québec-UL Research Center-Oncology Division, Quebec City, QC, G1R 3S3, Canada. jacques.cote@crhdq.ulaval.ca.ORCID http://orcid.org/0000-0001-6751-555X
Tatiana G KutateladzeDepartment of Pharmacology, University of Colorado School of Medicine, Aurora, CO, 80045, USA. tatiana.kutateladze@cuanschutz.edu.ORCID http://orcid.org/0000-0001-7375-6990
University of Colorado Denver · USVan Andel Institute · USWalter and Eliza Hall Institute of Medical Research · AUBaylor College of Medicine · USNational Institutes for Quantum Science and Technology · JPTexas A&M University · USUniversité Laval · CAUniversity of North Carolina at Chapel Hill · USAlbert Einstein College of Medicine · USHôtel-Dieu de Québec · CAUniversity of Colorado Anschutz Medical Campus · USUniversity of Pennsylvania · US
Funding
Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI David Darr · 1985 to 2026
$201.5MMechanisms of chromatin and transcriptional regulationR35GM126900 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Brian D Strahl · 2018 to 2026
$5.5MRole of GAS41 in Human CancerR01CA204020 · NCI · VAN ANDEL RESEARCH INSTITUTE · PI SHI, XIAOBING · 2016 to 2020
$2.0MEpigenetic regulation by PHF1R01GM106416 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI KUTATELADZE, TATIANA G · 2015 to 2018
$1.5MEpigenetic mechanisms for regulation of p300R01GM135671 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI KUTATELADZE, TATIANA G · 2020 to 2023
$1.4MMolecular mechanism of chromatin targeting by BRPF1R01GM100907 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI KUTATELADZE, TATIANA G · 2015 to 2018
$1.4MInterdomain crosstalk in MORC3R01GM125195 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI KUTATELADZE, TATIANA G · 2017 to 2021
$1.3MStudying Reversible Histone Acylations in Nucleosome ContextsR01GM121584 · NIGMS · TEXAS A&M UNIVERSITY · PI LIU, WENSHE RAY · 2017 to 2020
$1.3MMacromolecular X-ray Data Collection InstrumentationS10OD012033 · OD · UNIVERSITY OF COLORADO DENVER · PI CHURCHILL, MAIR E · 2014 to 2014
$421kNCI NIH HHS P30 CA016086NCI NIH HHS R01 CA204020NIGMS NIH HHS R01 GM100907NIGMS NIH HHS R01 GM106416NIGMS NIH HHS R01 GM121584NIGMS NIH HHS R01 GM125195NIGMS NIH HHS R01 GM135671NIGMS NIH HHS R35 GM126900NIH HHS S10 OD012033
Abstract
Acetylation of histone H3K23 has emerged as an essential posttranslational modification associated with cancer and learning and memory impairment, yet our understanding of this epigenetic mark remains insufficient. Here, we identify the native MORF complex as a histone H3K23-specific acetyltransferase and elucidate its mechanism of action. The acetyltransferase function of the catalytic MORF subunit is positively regulated by the DPF domain of MORF (MORF
Indexed as
Protein Processing, Post-TranslationalAcetylationAcylationBinding SitesCell Line, TumorCrystallography, X-RayHEK293 CellsHistone AcetyltransferasesHistonesHumansK562 CellsLysineMolecular Dynamics SimulationProtein BindingProtein DomainsHistone AcetyltransferasesHistonesKAT6B protein, humanLysine
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