ArticleScientific data2019
Linkage disequilibrium maps for European and African populations constructed from whole genome sequence data.
Article in Scientific data, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Article
- Polygenic prediction of human longevity on the supposition of pervasive pleiotropy.Scientific reports · 2024Article
- A Method to Study the Meiotic Recombination Map in Human Preimplantation Blastocysts.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Polygenic prediction of human longevity on the supposition of pervasive pleiotropy.medRxiv : the preprint server for health sciences · 2023Article
- Mapping of meiotic recombination in human preimplantation blastocysts.G3 (Bethesda, Md.) · 2023Article
- Genetic adaptation to pathogens and increased risk of inflammatory disorders in post-Neolithic Europe.Cell genomics · 2023Article
- Diversity in human genetics studies accelerates discovery and improves health care.Nature reviews. Cardiology · 2022Article
- African Genetic Representation in the Context of SARS-CoV-2 Infection and COVID-19 Severity.Frontiers in genetics · 2022Article
- Rare variant association testing in the non-coding genome.Human genetics · 2020Review
- Linkage disequilibrium maps for European and African populations constructed from whole genome sequence data.Scientific data · 2019Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Quantification of linkage disequilibrium (LD) patterns in the human genome is essential for genome-wide association studies, selection signature mapping and studies of recombination. Whole genome sequence (WGS) data provides optimal source data for this quantification as it is free from biases introduced by the design of array genotyping platforms. The Malécot-Morton model of LD allows the creation of a cumulative map for each choromosome, analogous to an LD form of a linkage map. Here we report LD maps generated from WGS data for a large population of European ancestry, as well as populations of Baganda, Ethiopian and Zulu ancestry. We achieve high average genetic marker densities of 2.3-4.6/kb. These maps show good agreement with prior, low resolution maps and are consistent between populations. Files are provided in BED format to allow researchers to readily utilise this resource.
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