Evidence map›Paper›PMID 31624227›Full record

ArticleTranslational psychiatry2019

Depression and suicide risk prediction models using blood-derived multi-omics data.

Youngjune Bhak, Hyoung-Oh Jeong, Yun Sung Cho, Sungwon Jeon, Juok Cho, Jeong-An Gim, Yeonsu Jeon, Asta Blazyte, Seung Gu Park, Hak-Min Kim and 10 more

Abstract read
In one paragraph

Article in Translational psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Multi-omics approaches to major psychiatric disorders.Neuropsychiatrie : Klinik, Diagnostik, Therapie und Rehabilitation : Organ der Gesellschaft Osterreichischer Nervenarzte und Psychiater · 2026
    Review
  7. Observational
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. The researcher's guide to selecting biomarkers in mental health studies.BioEssays : news and reviews in molecular, cellular and developmental biology · 2024
    Review
  17. Article
  18. Epigenome-wide Association Study for Tic Disorders in Children: A Preliminary Study in Korean Population.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2024
    Article
  19. Age Prediction Using DNA Methylation Heterogeneity Metrics.International journal of molecular sciences · 2024
    Article
  20. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Youngjune BhakKorean Genomics Industrialization and Commercialization Center (KOGIC), Ulsan National Institute of Science and Technology (UNIST), Ulsan, 44919, Republic of Korea.ORCID http://orcid.org/0000-0002-9273-6984
Hyoung-Oh JeongKorean Genomics Industrialization and Commercialization Center (KOGIC), Ulsan National Institute of Science and Technology (UNIST), Ulsan, 44919, Republic of Korea.
Yun Sung ChoClinomics Inc., Ulsan, 44919, Republic of Korea.
Sungwon JeonKorean Genomics Industrialization and Commercialization Center (KOGIC), Ulsan National Institute of Science and Technology (UNIST), Ulsan, 44919, Republic of Korea.
Juok ChoKorean Genomics Industrialization and Commercialization Center (KOGIC), Ulsan National Institute of Science and Technology (UNIST), Ulsan, 44919, Republic of Korea.
Jeong-An GimDepartment of Transdisciplinary Studies, Graduate School of Convergence Science and Technology, Seoul National University, Suwon, 16229, Republic of Korea.
Yeonsu JeonKorean Genomics Industrialization and Commercialization Center (KOGIC), Ulsan National Institute of Science and Technology (UNIST), Ulsan, 44919, Republic of Korea.ORCID http://orcid.org/0000-0003-4560-4142
Asta BlazyteKorean Genomics Industrialization and Commercialization Center (KOGIC), Ulsan National Institute of Science and Technology (UNIST), Ulsan, 44919, Republic of Korea.
Seung Gu ParkKorean Genomics Industrialization and Commercialization Center (KOGIC), Ulsan National Institute of Science and Technology (UNIST), Ulsan, 44919, Republic of Korea.ORCID http://orcid.org/0000-0001-6464-5551
Hak-Min KimKorean Genomics Industrialization and Commercialization Center (KOGIC), Ulsan National Institute of Science and Technology (UNIST), Ulsan, 44919, Republic of Korea.ORCID http://orcid.org/0000-0001-6066-2469
Eun-Seok ShinDivision of Cardiology, Department of Internal Medicine, Ulsan Medical Center, Ulsan, Republic of Korea.ORCID http://orcid.org/0000-0002-9169-6968
Jong-Woo PaikDepartment of Neuropsychiatry, College of Medicine, Kyung Hee University, Seoul, Republic of Korea.
Hae-Woo LeeDepartment of Psychiatry, Seoul Medical Center, Seoul, Republic of Korea.
Wooyoung KangDepartment of Biomedical Sciences, Korea University College of Medicine, Seoul, Republic of Korea.
Aram KimDepartment of Biomedical Sciences, Korea University College of Medicine, Seoul, Republic of Korea.
Yumi KimClinomics Inc., Ulsan, 44919, Republic of Korea.
Byung Chul KimClinomics Inc., Ulsan, 44919, Republic of Korea.
Byung-Joo HamDepartment of Biomedical Sciences, Korea University College of Medicine, Seoul, Republic of Korea.
Jong BhakKorean Genomics Industrialization and Commercialization Center (KOGIC), Ulsan National Institute of Science and Technology (UNIST), Ulsan, 44919, Republic of Korea. jongbhak@gmail.com.ORCID http://orcid.org/0000-0002-4228-1299
Semin LeeKorean Genomics Industrialization and Commercialization Center (KOGIC), Ulsan National Institute of Science and Technology (UNIST), Ulsan, 44919, Republic of Korea. seminlee@unist.ac.kr.ORCID http://orcid.org/0000-0002-9015-6046

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

More than 300 million people worldwide experience depression; annually, ~800,000 people die by suicide. Unfortunately, conventional interview-based diagnosis is insufficient to accurately predict a psychiatric status. We developed machine learning models to predict depression and suicide risk using blood methylome and transcriptome data from 56 suicide attempters (SAs), 39 patients with major depressive disorder (MDD), and 87 healthy controls. Our random forest classifiers showed accuracies of 92.6% in distinguishing SAs from MDD patients, 87.3% in distinguishing MDD patients from controls, and 86.7% in distinguishing SAs from controls. We also developed regression models for predicting psychiatric scales with R

Indexed as

EpigenomeTranscriptomeAdultCase-Control StudiesFemaleHumansMachine LearningMajor Depressive DisorderMaleMiddle AgedModels, PsychologicalPsychiatric Status Rating ScalesSuicide, AttemptedYoung Adult

Identifiers

PMID31624227
PMCPMC6797735

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.