Evidence map›Paper›PMID 31624149›Full record

ArticleThe Journal of biological chemistry2019

Ribosome depurination by ricin leads to inhibition of endoplasmic reticulum stress-induced

Michael Pierce, Diana Vengsarkar, John E McLaughlin, Jennifer N Kahn, Nilgun E Tumer

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Michael PierceDepartment of Plant Biology, School of Environmental and Biological Sciences, Rutgers University, New Brunswick, New Jersey 08901-8520.
Diana VengsarkarDepartment of Plant Biology, School of Environmental and Biological Sciences, Rutgers University, New Brunswick, New Jersey 08901-8520.
John E McLaughlinDepartment of Plant Biology, School of Environmental and Biological Sciences, Rutgers University, New Brunswick, New Jersey 08901-8520.
Jennifer N KahnDepartment of Plant Biology, School of Environmental and Biological Sciences, Rutgers University, New Brunswick, New Jersey 08901-8520.
Nilgun E TumerDepartment of Plant Biology, School of Environmental and Biological Sciences, Rutgers University, New Brunswick, New Jersey 08901-8520 tumer@sebs.rutgers.edu.
Rutgers, The State University of New Jersey · US

Funding

What makes ricin ToxicR01AI072425 · NIAID · RUTGERS, THE STATE UNIV OF N.J. · PI TUMER, NILGUN E · 2007 to 2021
$5.8M
NIAID NIH HHS R01 AI072425
6 · The paper itself

Abstract

Ricin undergoes retrograde transport to the endoplasmic reticulum (ER), and ricin toxin A chain (RTA) enters the cytosol from the ER. Previous reports indicated that RTA inhibits activation of the unfolded protein response (UPR) in yeast and in mammalian cells. Both precursor (preRTA) and mature form of RTA (mRTA) inhibited splicing of

Indexed as

Basic-Leucine Zipper Transcription FactorsEndoplasmic Reticulum StressGene Expression Regulation, FungalMembrane GlycoproteinsModels, BiologicalMutationProtein MultimerizationProtein Serine-Threonine KinasesPurinesRepressor ProteinsRibosomesRicinRNA, MessengerRNA Processing, Post-TranscriptionalRNA SplicingSaccharomyces cerevisiaeBasic-Leucine Zipper Transcription FactorsHAC1 protein, S cerevisiaeIRE1 protein, S cerevisiaeMembrane GlycoproteinsProtein Serine-Threonine KinasesPurinesRepressor ProteinsRicinRNA, MessengerSaccharomyces cerevisiae Proteinsalpha-sarcin/ricin loopendoplasmic reticulum stress (ER stress)HAC1/XBP1 splicingribosomal ribonucleic acid (rRNA) (ribosomal RNA)ribosomeribosome-inactivating protein (RIP)ricinRNA processingRNA splicingrRNA depurinationunfolded protein response (UPR)

Identifiers

PMID31624149
PMCPMC6879324
OpenAlexW2980949927

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.