ArticleProceedings of the National Academy of Sciences of the United States of America2019
Living myofibroblast-silicon composites for probing electrical coupling in cardiac systems.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Hydrogel-based neural engineering for skin wound healing.Frontiers in cell and developmental biology · 2026Review
- Illuminating the Underlying Mechanism of Intracellular Optoelectronic Modulation Using Silicon Nanowires.ACS nano · 2025Article
- Three-dimensional cellular construct with impregnated silicon nanowires for intracellular optoelectronic biointerface.Materials today. Bio · 2025Article
- Generation and applications of cardiac spheroids.npj biomedical innovations · 2025Review
- Implantable bioelectronic devices for photoelectrochemical and electrochemical modulation of cells and tissues.Nature reviews bioengineering · 2025Article
- Perspectives on non-genetic optoelectronic modulation biointerfaces for advancing healthcare.Med-X · 2024Article
- Advances in cardiac tissue engineering and heart-on-a-chip.Journal of biomedical materials research. Part A · 2024Review
- Article
- Bioresorbable thin-film silicon diodes for the optoelectronic excitation and inhibition of neural activities.Nature biomedical engineering · 2023Article
- Review
- Dissecting Biological and Synthetic Soft-Hard Interfaces for Tissue-Like Systems.Chemical reviews · 2022Review
- Electroconductive biomaterials for cardiac tissue engineering.Acta biomaterialia · 2022Review
- Synthetic recovery of impulse propagation in myocardial infarction via silicon carbide semiconductive nanowires.Nature communications · 2022Article
- Nanoenabled Bioelectrical Modulation.Accounts of materials research · 2021Article
- Fibroblast contributions to ischemic cardiac remodeling.Cellular signalling · 2021Review
- Recent advances in bioelectronics chemistry.Chemical Society reviews · 2020Review
- Soft-Hard Composites for Bioelectric Interfaces.Trends in chemistry · 2020Article
- Biological Interfaces, Modulation, and Sensing with Inorganic Nano-Bioelectronic Materials.Small methods · 2020Article
- Nano-enabled cellular engineering for bioelectric studies.Nano research · 2020Article
- Silicon Nanowires for Intracellular Optical Interrogation with Subcellular Resolution.Nano letters · 2020Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Traditional bioelectronics, primarily comprised of nonliving synthetic materials, lack cellular behaviors such as adaptability and motility. This shortcoming results in mechanically invasive devices and nonnatural signal transduction across cells and tissues. Moreover, resolving heterocellular electrical communication in vivo is extremely limited due to the invasiveness of traditional interconnected electrical probes. In this paper, we present a cell-silicon hybrid that integrates native cellular behavior (e.g., gap junction formation and biosignal processing) with nongenetically enabled photosensitivity. This hybrid configuration allows interconnect-free cellular modulation with subcellular spatial resolution for bioelectric studies. Specifically, we hybridize cardiac myofibroblasts with silicon nanowires and use these engineered hybrids to synchronize the electrical activity of cardiomyocytes, studying heterocellular bioelectric coupling in vitro. Thereafter, we inject the engineered myofibroblasts into heart tissues and show their ability to seamlessly integrate into contractile tissues in vivo. Finally, we apply local photostimulation with high cell specificity to tackle a long-standing debate regarding the existence of myofibroblast-cardiomyocyte electrical coupling in vivo.
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Registered trials
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