ArticleAJNR. American journal of neuroradiology2019
Prolonged Microgravity Affects Human Brain Structure and Function.
Article in AJNR. American journal of neuroradiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
61 citing papers in PubMed, 1 synthesis or guideline pooled it, 97 citations in OpenAlex.
- Effect of spaceflight experience on human brain structure, microstructure, and function: systematic review of neuroimaging studies.Brain imaging and behavior · 2024Pooled it
- An eye on long-duration spaceflight: Controversies, countermeasures and challenges.Experimental physiology · 2026Review
- A computational model of altered neuronal activity in altered gravity.NPJ microgravity · 2026Article
- Spaceflight-associated neuro-ocular syndrome (SANS): expert consensus on diagnosis and management.Eye (London, England) · 2026Review
- Neurological complications in microgravity and long duration spaceflight.NPJ microgravity · 2026Review
- The case for space as a model of accelerated aging.Nature aging · 2026Review
- Simulated microgravity affects neuronal synaptic plasticity by regulating microglial pro-inflammatory activation.NPJ microgravity · 2026Article
- The Final Frontier: Toward Transformative Insights into the Pathophysiologic Adaptations to Microgravity with Molecular Imaging.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026Article
- Neural activation is enhanced with operational task ecological validity during complex cognitive tasks.Frontiers in human neuroscience · 2026Article
- Effects of seasonal factors on brain function: Systematic review and future perspectives.iScience · 2025Article
- Radiation-induced Brain Injury and the Radiation Late Effects Cohort (RLEC) of Rhesus Macaques (Macaca mulatta).Radiation research · 2025Review
- Crewmember demographic factors and their association with brain and ocular changes following spaceflight.NPJ microgravity · 2025Article
- Transient gray matter decline during antarctic isolation: Roles of sleep, exercise, and cognition.NPJ microgravity · 2025Article
- Therapeutic Role of Probiotics in Gut-Brain Axis Under Microgravity.Indian journal of microbiology · 2025Review
- Navigating mental health in space: gut-brain axis and microbiome dynamics.Experimental & molecular medicine · 2025Review
- Spaceflight Associated Neuro-ocular Syndrome (SANS) and its countermeasures.Progress in retinal and eye research · 2025Review
- Dynamic Changes in Hindlimb Motor Cortex Neurons during Simulated Weightlessness Revealed by Miniature 2-Photon Microscopy.Research (Washington, D.C.) · 2025Article
- From astronauts to stroke survivors: how the TheraSuit Method® can boost balance and recovery.Frontiers in neurology · 2025Article
- Long-term effects of simulated microgravity in the central nervous system of rhesus monkeys: a voxel-wise multimodal MRI study.Frontiers in physiology · 2025Article
- Effect of artificial gravity on neurocognitive performance during head-down tilt bedrest.NPJ microgravity · 2024Article
1 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors at 6 institutions in 2 countries.
Funding
Abstract
background and purposeWidespread brain structural changes are seen following extended spaceflight missions. The purpose of this study was to investigate whether these structural changes are associated with alterations in motor or cognitive function. MATERIALS AND
methodsBrain MR imaging scans of National Aeronautics and Space Administration astronauts were retrospectively analyzed to quantify pre- to postflight changes in brain structure. Local structural changes were assessed using the Jacobian determinant. Structural changes were compared with clinical findings and cognitive and motor function.
resultsLong-duration spaceflights aboard the International Space Station, but not short-duration Space Shuttle flights, resulted in a significant increase in total ventricular volume (10.7% versus 0%,
conclusionsWhile cautious interpretation is appropriate given the small sample size and number of comparisons, these findings suggest that brain structural changes are associated with changes in cognitive and motor test scores and with the development of spaceflight-associated neuro-optic syndrome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.