ArticleJournal of the American Society of Echocardiography : official publication of the American Society of Echocardiography2020
Prognostic Significance of Echocardiographic Measures of Cardiac Remodeling.
Article in Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Impact of Blood Pressure in the Early 40s on Left Atrial Volumes in the Mid-60s: Data From the ACE 1950 Study.Journal of the American Heart Association · 2022Trial
- Effects of danicamtiv, a novel cardiac myosin activator, in heart failure with reduced ejection fraction: experimental data and clinical results from a phase 2a trial.European journal of heart failure · 2020Trial
- AlEuropean journal of nuclear medicine and molecular imaging · 2026Article
- Deep Learning-Enabled Assessment of Left Heart Structure and Function Predicts Cardiovascular Outcomes.Journal of the American College of Cardiology · 2023Article
- Multiple Prior Live Births Are Associated With Cardiac Remodeling and Heart Failure Risk in Women.Journal of cardiac failure · 2023Article
- Influence of angiotensin receptor-neprilysin inhibition on the efficacy of Empagliflozin on cardiac structure and function in patients with chronic heart failure and a reduced ejection fraction: The Empire HF trial.American heart journal plus : cardiology research and practice · 2023Article
- Role of confirmed and potential predictors of an unfavorable outcome in heart failure in everyday clinical practice.Irish journal of medical science · 2022Review
- Prognostic Significance of Echocardiographic Measures of Cardiac Remodeling in the Community.Current cardiology reports · 2021Review
- Associations Between HIV Serostatus and Cardiac Structure and Function Evaluated by 2-Dimensional Echocardiography in the Multicenter AIDS Cohort Study.Journal of the American Heart Association · 2021Observational
- Association of lung diffusion capacity with cardiac remodeling and risk of heart failure: The Framingham heart study.PloS one · 2021Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
backgroundIn recent decades, novel echocardiographic measures have constantly emerged. It is still unclear which echocardiographic measures have the most significant prognostic value in the general population. Accordingly, the aim of this study was to compare the prognostic value of a large panel of echocardiographic measures to identify the most promising measures.
methodsA total of 1,497 Framingham study participants (mean age, 65 years; 55.4% women) who underwent echocardiographic measurements of left ventricular ejection fraction, left ventricular mass index, global longitudinal strain, global circumferential strain, mitral annular plane systolic excursion, mitral E/e' ratio, maximum and minimum left atrial (LA) volume index, LA emptying fraction, and left ventricular longitudinal synchrony were evaluated. These measures were related to the incidence of two composite outcomes: cardiovascular disease (CVD) or death and atrial fibrillation (AF) or congestive heart failure (CHF).
resultsOn follow-up (mean, 8.3 years), there were 241 CVD events or deaths and 139 AF or CHF events. In multivariate-adjusted Cox models, higher LA emptying fraction was associated with a lower risk (hazard ratios per SD, 0.80 and 0.70 for CVD or death and AF or CHF, respectively; P ≤ .001 for both) while higher minimum LA volume index (hazard ratios per SD, 1.32 and 1.70 for CVD or death and AF or CHF, respectively; P ≤ .001 for both) and maximum LA volume index (hazard ratios per SD, 1.26 and 1.54 for CVD or death and AF or CHF, respectively; P ≤ .002 for both) were associated with a higher risk for both composite outcomes.
conclusionsIn this community-based sample, LA volumes and function were the best echocardiographic predictors of clinical outcomes. Therefore, these values should be considered for inclusion in standard echocardiographic assessments for the purpose of risk stratification.
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