Evidence map›Paper›PMID 31623952›Full record

ArticleTrends in parasitology2019

Structure Solves the Problem with Malaria Merozoite Vaccines.

Patrick E Duffy

Abstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Trends in parasitology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author.

Patrick E DuffyLaboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. Electronic address: patrick.duffy@nih.gov.

Funding

Malaria Vaccine: AMA1-C1ZIAAI001001 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI DUFFY, PATRICK · 2009 to 2012
$5.1M
Malaria Vaccine: AMA1-C1/ISA 720ZIAAI001005 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI DUFFY, PATRICK · 2009 to 2011
$1.6M
Intramural NIH HHS ZIA AI001001Intramural NIH HHS ZIA AI001005
6 · The paper itself

Abstract

Malaria vaccines targeting merozoite invasion of erythrocytes have long held appeal but failed in clinical trials. Three structural studies of antibody-antigen complexes by Alanine et al., Urusova et al., and Rawlinson et al. define neutralizing and nonneutralizing epitopes in essential invasion proteins, leading to rational design of improved merozoite vaccines.

Indexed as

MalariaMalaria VaccinesProtozoan ProteinsAnimalsAntibodies, ProtozoanErythrocytesHumansMerozoitesPlasmodium vivaxAntibodies, ProtozoanMalaria VaccinesProtozoan Proteinsepitopesmalaria vaccineneutralizing antibodyPlasmodium falciparumPlasmodium vivaxX-ray crystallography

Identifiers

PMID31623952
PMCPMC11131090

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.