Evidence map›Paper›PMID 31623867›Full record

ArticleTrends in neurosciences2019

Microglial Self-Recognition STINGs in A-T Neurodegeneration.

Austin Ferro, Carrie Sheeler, Marija Cvetanovic

Open access · greenAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Trends in neurosciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. DNA Repair Inhibition Leads to Active Export of Repetitive Sequences to the Cytoplasm Triggering an Inflammatory Response.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Austin FerroDepartment of Neuroscience, University of Minnesota, 2101 6th Street South East, Minneapolis, MN 55455, USA.
Carrie SheelerDepartment of Neuroscience, University of Minnesota, 2101 6th Street South East, Minneapolis, MN 55455, USA.
Marija CvetanovicDepartment of Neuroscience, University of Minnesota, 2101 6th Street South East, Minneapolis, MN 55455, USA; Institute for Translational Neuroscience, University of Minnesota, 2101 6th Street South East, Minneapolis, MN 55455, USA. Electronic address: mcvetano@umn.edu.
University of Minnesota · US

Funding

Understanding cellular and molecular mechanisms of neurodegenerationR01NS107387 · NINDS · UNIVERSITY OF MINNESOTA · PI CVETANOVIC, MARIJA · 2018 to 2021
$1.3M
BIMODAL FUNCTION OF ASTROGLIA IN SCA1 DISEASE PROGRESSIONF31NS103392 · NINDS · UNIVERSITY OF MINNESOTA · PI FERRO, AUSTIN · 2018 to 2020
$114k
NINDS NIH HHS F31 NS103392NINDS NIH HHS R01 NS107387
6 · The paper itself

Abstract

Microglial inflammation is often seen as a secondary event in neurodegeneration. A recent study by Song et al. demonstrates that loss of ataxia telangiectasia mutated (ATM) activates microglia through the cytosolic DNA sensor STING. This highlights the ability of microglia to recognize and respond to self-DNA, with potentially neurotoxic consequences.

Indexed as

Ataxia TelangiectasiaAtaxia Telangiectasia Mutated ProteinsDNAHumansInflammationMicrogliaAtaxia Telangiectasia Mutated ProteinsATM protein, humanDNAataxia telangiectasiaATMmicrogliaNF-κB

Identifiers

PMID31623867
PMCPMC7178899
OpenAlexW2980410946

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.