Evidence map›Paper›PMID 31623608›Full record

ArticleJournal of nanobiotechnology2019

pH and redox dual-responsive nanoparticles based on disulfide-containing poly(β-amino ester) for combining chemotherapy and COX-2 inhibitor to overcome drug resistance in breast cancer.

Sipei Zhang, Nan Guo, Guoyun Wan, Tao Zhang, Chunyu Li, Yongfei Wang, Yinsong Wang, Yuanyuan Liu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 81 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Sipei ZhangTianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy; Department of Genetics, School of Basic Medical Sciences; Department of Integrated Traditional Chinese and Western Medicine, International Medical School, Tianjin Medical University, Qixiangtai Road 22, Tianjin, 300070, China.
Nan GuoTianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy; Department of Genetics, School of Basic Medical Sciences; Department of Integrated Traditional Chinese and Western Medicine, International Medical School, Tianjin Medical University, Qixiangtai Road 22, Tianjin, 300070, China.
Guoyun WanTianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy; Department of Genetics, School of Basic Medical Sciences; Department of Integrated Traditional Chinese and Western Medicine, International Medical School, Tianjin Medical University, Qixiangtai Road 22, Tianjin, 300070, China.
Tao ZhangTianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy; Department of Genetics, School of Basic Medical Sciences; Department of Integrated Traditional Chinese and Western Medicine, International Medical School, Tianjin Medical University, Qixiangtai Road 22, Tianjin, 300070, China.
Chunyu LiTianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy; Department of Genetics, School of Basic Medical Sciences; Department of Integrated Traditional Chinese and Western Medicine, International Medical School, Tianjin Medical University, Qixiangtai Road 22, Tianjin, 300070, China.
Yongfei WangChoate Rosemary Hall, Class of 2019, Wallingford, CT, 06492, USA.
Yinsong WangTianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy; Department of Genetics, School of Basic Medical Sciences; Department of Integrated Traditional Chinese and Western Medicine, International Medical School, Tianjin Medical University, Qixiangtai Road 22, Tianjin, 300070, China. wangyinsong@tmu.edu.cn.
Yuanyuan LiuTianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy; Department of Genetics, School of Basic Medical Sciences; Department of Integrated Traditional Chinese and Western Medicine, International Medical School, Tianjin Medical University, Qixiangtai Road 22, Tianjin, 300070, China. liuyuanyuan01@tmu.edu.cn.
Theranostics (New Zealand) · NZPediatrics and Genetics · USChoate Rosemary Hall · USTianjin Medical University · CN

Funding

National Natural Science Foundation of China 81573005National Natural Science Foundation of China 81602724National Natural Science Foundation of China 81803101Natural Science Foundation of Tianjin City 18JCQNJC83100Natural Science Foundation of Tianjin City 18JCZDJC33400
6 · The paper itself

Abstract

backgroundMultidrug resistance (MDR) generally leads to breast cancer treatment failure. The most common mechanism of MDR is the overexpression of ATP-binding cassette (ABC) efflux transporters such as P-glycoprotein (P-gp) that reduce the intracellular accumulation of various chemotherapeutic agents. Celecoxib (CXB), a selective COX-2 inhibitor, can dramatically enhance the cytotoxicity of doxorubicin (DOX) in breast cancer cells overexpressing P-gp. Thus it can be seen that the combination of DOX and CXB maybe obtain synergistic effects against breast cancer by overcoming drug resistance.

resultsIn this study, we designed a pH and redox dual-responsive nanocarrier system to combine synergistic effects of DOX and CXB against drug resistant breast cancer. This nanocarrier system denoted as HPPDC nanoparticles showed good in vitro stability and significantly accelerated drug releases under the acidic and redox conditions. In drug-resistant human breast cancer MCF-7/ADR cells, HPPDC nanoparticles significantly enhanced the cellular uptake of DOX through the endocytosis mediated by CD44/HA specific binding and the down-regulated P-gp expression induced by COX-2 inhibition, and thus notably increased the cytotoxicity and apoptosis-inducing activity of DOX. In MCF-7/ADR tumor-bearing nude mice, HPPDC nanoparticles showed excellent tumor-targeting ability, remarkably enhanced tumor chemosensitivity and reduced COX-2 and P-gp expressions in tumor tissues.

conclusionAll results demonstrated that HPPDC nanoparticles can efficiently overcome drug resistance in breast cancer both in vitro and in vivo by combining chemotherapy and COX-2 inhibitor. In a summary, HPPDC nanoparticles show a great potential for combination treatment of drug resistant breast cancer.

Indexed as

AnimalsBreast NeoplasmsCelecoxibCyclooxygenase 2 InhibitorsDelayed-Action PreparationsDoxorubicinDrug Resistance, NeoplasmFemaleHumansHydrogen-Ion ConcentrationMCF-7 CellsMice, NudeNanoparticlesOxidation-ReductionPolymersCelecoxibCyclooxygenase 2 InhibitorsDelayed-Action PreparationsDoxorubicinpoly(beta-amino ester)PolymersBreast cancerCelecoxibDrug resistanceNanoparticlepH and redox dual-responsive

Identifiers

PMID31623608
PMCPMC6798417
OpenAlexW2981028410

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.