Evidence map›Paper›PMID 31623522›Full record

ArticleCirculation research2020

Triglyceride Paradox Is Related to Lipoprotein Size, Visceral Adiposity and Stearoyl-CoA Desaturase Activity in Black Versus White Women.

Stephanie T Chung, Celeste K L Cravalho, Abby G Meyers, Amber B Courville, Shanna Yang, Nirupa Rachel Matthan, Lilian Mabundo, Maureen Sampson, Ronald Ouwerkerk, Ahmed M Gharib and 3 more

Registry-linked trialOpen access · bronzeAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01809288 (Identifying Risk for Diabetes and Heart Disease in Women), which is not on this map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01809288 completednot on this map

Identifying Risk for Diabetes and Heart Disease in Women: A Study of African-American, African and White Federal Employees and Contractors

TypeobservationalSponsorNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)Ran2013Enrolled149ConditionsObesity, Insulin Resistance, Triglycerides, Diabetes
3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

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  12. Vitamin C Urinary Loss and Deficiency in Human Immunodeficiency Virus (HIV): Cross-sectional Study of Vitamin C Renal Leak in Women With HIV.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 2 countries.

Stephanie T ChungFrom the Intramural Program of National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD (S.T.C., C.K.L.C., L.M., R.O., A.M.G., A.E.S.).
Celeste K L CravalhoFrom the Intramural Program of National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD (S.T.C., C.K.L.C., L.M., R.O., A.M.G., A.E.S.).
Abby G MeyersIntramural Program of National Institute of Child Health and Development, National Institutes of Health, MD (A.G.M.).
Amber B CourvilleNIH Clinical Center, Bethesda, MD (A.B.C., S.Y.).
Shanna YangNIH Clinical Center, Bethesda, MD (A.B.C., S.Y.).
Nirupa Rachel MatthanCardiovascular Nutrition Laboratory, USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA (N.R.M., A.H.L.).
Lilian MabundoFrom the Intramural Program of National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD (S.T.C., C.K.L.C., L.M., R.O., A.M.G., A.E.S.).
Maureen SampsonNational Heart, Lung, and Blood Institute, Bethesda, MD (M.S., A.T.R.).
Ronald OuwerkerkFrom the Intramural Program of National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD (S.T.C., C.K.L.C., L.M., R.O., A.M.G., A.E.S.).
Ahmed M GharibFrom the Intramural Program of National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD (S.T.C., C.K.L.C., L.M., R.O., A.M.G., A.E.S.).
Alice H LichtensteinCardiovascular Nutrition Laboratory, USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA (N.R.M., A.H.L.).
Alan T RemaleyNational Heart, Lung, and Blood Institute, Bethesda, MD (M.S., A.T.R.).
Anne E SumnerFrom the Intramural Program of National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD (S.T.C., C.K.L.C., L.M., R.O., A.M.G., A.E.S.).
National Institutes of Health · USNational Heart Lung and Blood Institute · USNational Institute of Diabetes and Digestive and Kidney Diseases · USNational Institutes of Health Clinical Center · USTufts University · USNational Institute of Child Health · HU

Funding

New York Regional Center for Diabetes Translation Research - Translational Intervention Methodology CoreP30DK111022 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI JEFFREY GONZALEZ · 2016 to 2026
$7.8M
Nested Study: Identifying Risk for Diabetes and Heart Disease in Women: A Study of African-American, African and White Federal Employees and ContractorsZIADK075105 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI CHUNG, STEPHANIE THERESE · 2014 to 2025
$1.8M
Intramural NIH HHS Z99 DK999999NIDDK NIH HHS P30 DK111022
6 · The paper itself

Abstract

rationaleIn black women, triglycerides are paradoxically normal in the presence of insulin resistance. This relationship may be explained by race-related differences in central adiposity and SCD (stearoyl-CoA desaturase)-1 enzyme activity index.

objectiveIn a cross-sectional study, to compare fasting and postprandial triglyceride-rich lipoprotein particle (TRLP) concentrations and size in black compared with white pre- and postmenopausal women and determine the relationship between TRLP subfractions and whole-body insulin sensitivity, hepatic and visceral fat, and SCD-1 levels. METHODS AND

resultsIn 122 federally employed women without diabetes mellitus, 73 black (58 African American and 15 African immigrant) and 49 white; age, 44±10 (mean±SD) years; body mass index, 30.0±5.6 kg/m

conclusionsLower visceral fat and SCD-1 activity may contribute to the paradoxical association of lower fasting and postprandial TRLP subfractions despite insulin resistance in black compared with white pre- and postmenopausal women. Similar concentrations of very small TRLPs are related to insulin resistance and could be important mediators of cardiometabolic disease risk in women. CLINICAL

trial registrationURL: http://www.clinicaltrials.gov. Unique identifier: NCT01809288.

Indexed as

Black PeopleWhite PeopleAdiposityAdultAfricaBlack or African AmericanBlood GlucoseCross-Sectional StudiesDiabetes Mellitus, Type 2Disease SusceptibilityEmigrants and ImmigrantsEnergy IntakeFastingFemaleHumansInsulin ResistanceBlood GlucoseLipoproteinsStearoyl-CoA DesaturaseTriglyceridescontinental population groupshumansinsulin resistanceliverobesity

Identifiers

PMID31623522
PMCPMC7243466
OpenAlexW2980684663

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.