ArticleJournal of dental research2019
Subgingival Microbiota and Longitudinal Glucose Change: The Oral Infections, Glucose Intolerance and Insulin Resistance Study (ORIGINS).
Article in Journal of dental research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- The Factors Affecting Orthodontic Pain with Periodontitis.Journal of healthcare engineering · 2021Trial
- Comparative machine learning analysis of saliva and plaque microbiomes in Kuwaitis with type 1 diabetes.Frontiers in microbiology · 2026Article
- Integrative analyses of 16S rDNA sequencing and serum metabolomics demonstrate significant roles for the oral microbiota and serum metabolites in post-kidney transplant diabetes mellitus.Microbiology spectrum · 2025Article
- Association Between Dietary Patterns and Subgingival Microbiota: Results From the Oral Infections, Glucose Intolerance, and Insulin Resistance Study (ORIGINS).Journal of clinical periodontology · 2025Article
- Clinical attachment loss is cross-sectionally associated with elevated glucose among adults without diabetes.Journal of clinical periodontology · 2024Article
- Longitudinal profiling of the microbiome at four body sites reveals core stability and individualized dynamics during health and disease.Cell host & microbe · 2024Article
- Hyperglycemia is associated with duodenal dysbiosis and altered duodenal microenvironment.Scientific reports · 2023Article
- Periodontitis as a promoting factor of T2D: current evidence and mechanisms.International journal of oral science · 2023Review
- Multi-Omics Data Integration Reveals Key Variables Contributing to Subgingival Microbiome Dysbiosis-Induced Inflammatory Response in a Hyperglycemic Microenvironment.International journal of molecular sciences · 2023Article
- A Positive or Negative Connection of Diabetes Mellitus to the Oral Microbiota.The Eurasian journal of medicine · 2023Article
- Current scientific evidence for why periodontitis should be included in diabetes management.Frontiers in clinical diabetes and healthcare · 2023Article
- Enrichment of sulphate-reducers and depletion of butyrate-producers may be hyperglycaemia signatures in the diabetic oral microbiome.Journal of oral microbiology · 2022Article
- Cross-Cohort Microbiome Analysis of Salivary Biomarkers in Patients With Type 2 Diabetes Mellitus.Frontiers in cellular and infection microbiology · 2022Article
- Bacterial colonization of explanted non-endocarditis cardiac valves: evidence and characterization of the valvular microbiome.Interactive cardiovascular and thoracic surgery · 2021Article
- Assessing the Relationship Between Nitrate-Reducing Capacity of the Oral Microbiome and Systemic Outcomes.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Association Between Serum Thyroid-Stimulating Hormone Levels and Salivary Microbiome Shifts.Frontiers in cellular and infection microbiology · 2021Article
- Taxonomic diversity of sputum microbiome in lung cancer patients and its relationship with chromosomal aberrations in blood lymphocytes.Scientific reports · 2020Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
Microbial communities along mucosal surfaces throughout the digestive tract are hypothesized as risk factors for impaired glucose regulation and the development of clinical cardiometabolic disease. We investigated whether baseline measures of subgingival microbiota predicted fasting plasma glucose (FPG) longitudinally. The Oral Infections, Glucose Intolerance and Insulin Resistance Study (ORIGINS) enrolled 230 diabetes-free adults (77% female) aged 20 to 55 y (mean ± SD, 34 ± 10 y) from whom baseline subgingival plaque and longitudinal FPG were measured. DNA was extracted from subgingival plaque, and V3 to V4 regions of the 16S rRNA gene were sequenced. FPG was measured at baseline and again at 2 y; glucose change was defined as follow-up minus baseline. Multivariable linear models regressed 2-y glucose change onto baseline measures of community diversity and abundances of 369 individual taxa. A microbial dysbiosis index (MDI) summarizing top individual taxa associated with glucose change was calculated and used in regression models. Models were adjusted for age, sex, race/ethnicity, education, smoking status, body mass index, and baseline glucose levels. Statistical significance was based on the false discovery rate (FDR; <0.05) or a Bonferroni-corrected
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.