ArticleJournal of dental research2020
Mesenchymal Progenitor Regulation of Tooth Eruption: A View from PTHrP.
Article in Journal of dental research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07587567 (Determination of Risk Factors for Eruption Disorders in the Primary and Permanent Dentition), which is not on this map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Determination of Risk Factors for Eruption Disorders in the Primary and Permanent Dentition
Who cites it
32 citing papers in PubMed, 63 citations in OpenAlex.
- Stem-cell regulation in periodontium formation and regeneration.Journal of bone and mineral metabolism · 2026Review
- Resolving tooth development at single-cell resolution: advancing dental regeneration.Frontiers in cell and developmental biology · 2026Review
- Effect of maternal COVID-19 vaccination on mandibular molars development in albino rats offspring.Scientific reports · 2025Article
- Permanent first molar eruption failure in children: leading signs for early diagnosis.Progress in orthodontics · 2025Observational
- A Hedgehog-Foxf axis coordinates dental follicle-derived alveolar bone formation.Nature communications · 2025Article
- Wnt-directed CXCL12-expressing apical papilla progenitor cells drive tooth root formation.Nature communications · 2025Article
- Control of alveolar bone development, homeostasis, and socket healing by salt-inducible kinases.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2025Article
- A novel PTH1R mutation causes primary failure of eruption via the cAMP-PI3K/AKT pathway.Progress in orthodontics · 2025Article
- Impact of parathyroid Hormone's dose, timing, and delivery mode on osteoclastogenesis and osteogenesis using a human periodontal ligament fibroblast model.Frontiers in pharmacology · 2025Article
- Surgical Removal of Impacted Lower Second Molar in Transverse Position: A Case Report.Case reports in dentistry · 2025Article
- Resilience of the replacing dentition in adult reptiles.Developmental biology · 2024Review
- Eruption Disturbance in Children Receiving Bisphosphonates: Two Case Reports.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Abnormal dental follicle cells: A crucial determinant in tooth eruption disorders (Review).Molecular medicine reports · 2024Review
- Rare Case of First Permanent Molar Primary Failure of Eruption with Agenesis of Premolars.Children (Basel, Switzerland) · 2024Article
- Effects of antiresorptive medications on tooth root formation and tooth eruption in paediatric patients.Orthodontics & craniofacial research · 2023Review
- Epigenetic Regulation in Oral Squamous Cell Carcinoma Microenvironment: A Comprehensive Review.Cancers · 2023Review
- Mechanisms of Osteoclastogenesis in Orthodontic Tooth Movement and Orthodontically Induced Tooth Root Resorption.Journal of bone metabolism · 2023Article
- Evaluation of Current Studies to Elucidate Processes in Dental Follicle Cells Driving Osteogenic Differentiation.Biomedicines · 2023Review
- Identification of a novel PTH1R variant in a family with primary failure of eruption.BMC oral health · 2023Article
- Effect of local injection of injectable platelet-rich fibrin on eruption rate of teeth (Rabbit animal model).Journal of orthodontic science · 2023Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Tooth eruption is a unique biological process by which highly mineralized tissues emerge into the outer world, and it occurs concomitantly with tooth root formation. These 2 processes have been considered independent phenomena; however, recent studies support the theory that they are indeed intertwined. Dental mesenchymal progenitor cells in the dental follicle lie at the heart of the coupling of these 2 processes, providing a source for diverse mesenchymal cells that support formation of the highly functional tooth root and the periodontal attachment apparatus, while facilitating formation of osteoclasts. These cells are regulated by autocrine signaling by parathyroid hormone-related protein (PTHrP) and its parathyroid hormone/PTHrP receptor PPR. This PTHrP-PPR signaling appears to crosstalk with other signaling pathways and regulates proper cell fates of mesenchymal progenitor cell populations. Disruption of this autocrine PTHrP-PPR signaling in these cells leads to defective formation of the periodontal attachment apparatus, tooth root malformation, and failure of tooth eruption in molars, which essentially recapitulate primary failure of eruption in humans, a rare genetic disorder exclusively affecting tooth eruption. Diversity and distinct functionality of these mesenchymal progenitor cell populations that regulate tooth eruption and tooth root formation are beginning to be unraveled.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.