ReviewExpert opinion on investigational drugs2019
BIIB093 (IV glibenclamide): an investigational compound for the prevention and treatment of severe cerebral edema.
Open access · greenAbstract readReview
In one paragraph
Review in Expert opinion on investigational drugs, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 1 pooled it
9.1field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- Sulfonylurea drugs for people with severe hemispheric ischemic stroke.The Cochrane database of systematic reviews · 2025Pooled it
- Safety and Feasibility of YC-6 in Patients With Large Hemispheric Infarction: A Randomized Clinical Trial.Journal of the American Heart Association · 2025Trial
- SUR1-TRPM4 is expressed in human epilepsy and promotes neuron hyperactivity and seizures in rodents.Brain : a journal of neurology · 2026Article
- Structural biology of the TRPM4 channel: architecture, modulation, and therapeutic opportunities.Frontiers in pharmacology · 2026Review
- Article
- The Relationship Between Inflammation and the Development of Cerebral Ischaemia and Hypoxia in Traumatic Brain Injury-A Narrative Review.International journal of molecular sciences · 2025Review
- Delayed neurological recovery in ischemic stroke patients undergoing endovascular treatment is associated with baseline hyperglycemia: a treatable cause of the stunned brain phenomenon?Journal of neurology · 2025Observational
- Intranasal Mucoadhesive In Situ Gel of Glibenclamide-Loaded Bilosomes for Enhanced Therapeutic Drug Delivery to the Brain.Pharmaceutics · 2025Article
- Resveratrol Prevents Cell Swelling Through Inhibition of SUR1 Expression in Brain Micro Endothelial Cells Subjected to OGD/Recovery.Molecular neurobiology · 2024Article
- Effect of short- versus long-term serum glucose levels on early ischemic water homeostasis and functional outcome in patients with large vessel occlusion stroke.European journal of neurology · 2024Article
- Validation and refinement of a predictive nomogram using artificial intelligence: assessing in-hospital mortality in patients with large hemispheric cerebral infarction.Frontiers in neurology · 2024Article
- Interleukin-6 in Traumatic Brain Injury: A Janus-Faced Player in Damage and Repair.Journal of neurotrauma · 2023Review
- Outcomes in Patients with Aneurysmal Subarachnoid Hemorrhage Receiving Sulfonylureas: A Propensity-Adjusted Analysis.World neurosurgery · 2023Article
- Ion Channels as Potential Tools for the Diagnosis, Prognosis, and Treatment of HPV-Associated Cancers.Cells · 2023Review
- Research progress on pleiotropic neuroprotective drugs for traumatic brain injury.Frontiers in pharmacology · 2023Review
- Brain edema formation and therapy after intracerebral hemorrhage.Neurobiology of disease · 2023Review
- Global changes in diffusion tensor imaging during acute ischemic stroke and post-stroke cognitive performance.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Article
- How can imaging in acute ischemic stroke help us to understand tissue fate in the era of endovascular treatment and cerebroprotection?Neuroradiology · 2022Article
- Macamide B Pretreatment Attenuates Neonatal Hypoxic-Ischemic Brain Damage of Mice Induced Apoptosis and Regulates Autophagy via the PI3K/AKT Signaling Pathway.Molecular neurobiology · 2022Article
- The effect of Glibenclamide on somatosensory evoked potentials after cardiac arrest in rats.Neurocritical care · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Melissa PergakisDepartment of Neurology, University of Maryland School of Medicine, Baltimore, MD, USA.
Neeraj BadjatiaDepartment of Neurology, University of Maryland School of Medicine, Baltimore, MD, USA.
Seemant ChaturvediDepartment of Neurology, University of Maryland School of Medicine, Baltimore, MD, USA.
Carolyn A CroninDepartment of Neurology, University of Maryland School of Medicine, Baltimore, MD, USA.
W Taylor KimberlyDivision of Neurocritical Care and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
Kevin N ShethDivision of Neurocritical Care, Department of Neurology, Yale University School of Medicine, New Haven, CT, USA.
J Marc SimardDepartment of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD, USA.
University of Maryland, Baltimore · USMassachusetts General Hospital · USYale University · US
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MAnticoagulation in ICH Survivors for Prevention and Recovery (ASPIRE)U01NS106513 · NINDS · YALE UNIVERSITY · PI Hooman Kamel, Kevin Navin Sheth · 2019 to 2026
$20.6MSulfonylurea receptor 1 (SUR1)- A novel therapeutic target in ischemic strokeR01HL082517 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI SIMARD, J. MARC · 2006 to 2021
$5.6MLongitudinal Sub-thalamic Structure and Functional Alterations in Mild Traumatic Brain InjuryR01NS105503 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI BADJATIA, NEERAJ, PRINCE, JERRY L · 2018 to 2022
$3.5MThe Recovery in Stroke Using PAP (RISE UP) StudyR01NR018335 · NINR · YALE UNIVERSITY · PI REDEKER, NANCY S, SHETH, KEVIN NAVIN · 2019 to 2023
$3.4MSpinal cord injury, progressive hemorrhagic necrosis and the NC(Ca-ATP) channelR01NS060801 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI SIMARD, J. MARC · 2009 to 2018
$3.3MSouthern New England Partnership In Stroke Research, Innovation and Treatment (SPIRIT)U24NS107215 · NINDS · YALE UNIVERSITY · PI MARK Jay ALBERTS, Karen L Furie · 2018 to 2026
$3.0MMetabolomic predictors of stroke in REGARDSR01NS099209 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI KIMBERLY, WILLIAM TAYLOR · 2017 to 2021
$2.4MFn14, non-canonical NF-kappaB and downstream signaling in neuropathic painR01NS105633 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI SIMARD, J. MARC · 2018 to 2022
$1.9MNon-canonical NF-kappaB signaling and Sur1-Trpm4 in traumatic brain injuryR01NS102589 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI SIMARD, J. MARC · 2017 to 2021
$1.7MYale Clinical Site: Investigations For Improved Neurological Treatments at Yale (INFINITY)U24NS107136 · NINDS · YALE UNIVERSITY · PI SHETH, KEVIN NAVIN, SPUDICH, SERENA S · 2018 to 2022
$1.7MIntensive Blood Pressure Reduction in Deep Intracerebral HemorrhageR03NS112859 · NINDS · YALE UNIVERSITY · PI FALCONE, GUIDO JOSE, SHETH, KEVIN NAVIN · 2019 to 2020
$84kBLRD VA I01 BX002889NCATS NIH HHS UL1 TR001863NHLBI NIH HHS R01 HL082517NINDS NIH HHS R01 NS060801NINDS NIH HHS R01 NS099209NINDS NIH HHS R01 NS102589NINDS NIH HHS R01 NS105503NINDS NIH HHS R01 NS105633NINDS NIH HHS R03 NS112859NINDS NIH HHS U01 NS106513NINDS NIH HHS U24 NS107136NINDS NIH HHS U24 NS107215NINR NIH HHS R01 NR018335
Abstract
PubMed holds no abstract for this paper.
Indexed as
Administration, IntravenousAnimalsBrain EdemaDrugs, InvestigationalGlyburideHumansNeuroprotective AgentsSeverity of Illness IndexDrugs, InvestigationalGlyburideNeuroprotective AgentsBIIB093cerebral edemacontusionGlibenclamidelarge hemispheric infarctionstrokeSUR1-TRPM4traumatic brain injury
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.