ArticleLife (Basel, Switzerland)2019
Survival of Self-Replicating Molecules under Transient Compartmentalization with Natural Selection.
Article in Life (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Experimental evolution toward extinction in a molecular host-parasite system.Molecular biology and evolution · 2026Article
- Compositional memory matters for early molecular systems.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Darwinian Evolution of Self-Replicating DNA in a Synthetic Protocell.Nature communications · 2024Article
- Evolutionary Game-Theoretic Approach to the Population Dynamics of Early Replicators.Life (Basel, Switzerland) · 2024Article
- Coevolution of reproducers and replicators at the origin of life and the conditions for the origin of genomes.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Growth, replication and division enable evolution of coacervate protocells.Chemical communications (Cambridge, England) · 2022Review
- Primitive Compartmentalization for the Sustainable Replication of Genetic Molecules.Life (Basel, Switzerland) · 2021Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The problem of the emergence and survival of self-replicating molecules in origin-of-life scenarios is plagued by the error catastrophe, which is usually escaped by considering effects of compartmentalization, as in the stochastic corrector model. By addressing the problem in a simple system composed of a self-replicating molecule (a replicase) and a parasite molecule that needs the replicase for copying itself, we show that transient (rather than permanent) compartmentalization is sufficient to the task. We also exhibit a regime in which the concentrations of the two kinds of molecules undergo sustained oscillations. Our model should be relevant not only for origin-of-life scenarios but also for describing directed evolution experiments, which increasingly rely on transient compartmentalization with pooling and natural selection.
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Registered trials
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