Evidence map›Paper›PMID 31623383›Full record

ArticleMetabolites2019

Reactive Carbonyl Species as Potential Pro-Oxidant Factors Involved in Lichen Planus Pathogenesis.

Madalina Irina Mitran, Ilinca Nicolae, Mircea Tampa, Cristina Iulia Mitran, Constantin Caruntu, Maria Isabela Sarbu, Corina Daniela Ene, Clara Matei, Simona Roxana Georgescu, Mircea Ioan Popa

Open access · goldAbstract read
In one paragraph

Article in Metabolites, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Review
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  5. Article
  6. Review
  7. Review
  8. Thiol-Disulfide Homeostasis in Skin Diseases.Journal of clinical medicine · 2022
    Review
  9. Review
  10. Article
  11. Article
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  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Madalina Irina MitranDepartment of Microbiology, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania. irina.mitran@drd.umfcd.ro.
Ilinca Nicolae"Victor Babes" Clinical Hospital for Infectious Diseases, 030303 Bucharest, Romania. ilincanicolae84@gmail.com.
Mircea Tampa"Victor Babes" Clinical Hospital for Infectious Diseases, 030303 Bucharest, Romania. dermatology.mt@gmail.com.
Cristina Iulia MitranDepartment of Microbiology, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania. cristina.mitran@drd.umfcd.ro.
Constantin CaruntuDepartment of Physiology, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania. costin.caruntu@gmail.com.
Maria Isabela SarbuDepartment of Dermatology, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania. maria.sarbu@umfcd.ro.
Corina Daniela Ene"Carol Davila" Nephrology Hospital, 010731 Bucharest; Romania. corina.daniela.ene85@gmail.com.
Clara MateiDepartment of Dermatology, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania. dermatology.cm@gmail.com.
Simona Roxana Georgescu"Victor Babes" Clinical Hospital for Infectious Diseases, 030303 Bucharest, Romania. srg.dermatology@gmail.com.
Mircea Ioan PopaDepartment of Microbiology, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania. mircea.ioan.popa@gmail.com.ORCID 0000-0002-0794-9329
Carol Davila University of Medicine and Pharmacy · ROSpitalul Clinic Dr. Victor Babes · RO

Funding

Ministerul Educației și Cercetării Științifice 61PCCDI⁄2018 PN-III-P1-1.2-PCCDI-2017-0341
6 · The paper itself

Abstract

The constant generation of reactive carbonyl species (RCSs) by lipid peroxidation during aerobic metabolism denotes their involvement in cell homeostasis. Skin represents the largest organ of the body that is exposed to lipid peroxidation. Previous studies have suggested the involvement of oxidative stress in the development of lichen planus (LP), a chronic inflammatory skin condition with a complex pathogenesis. The aim of our study is to investigate a panel of pro-oxidants (4-hydroxy-nonenal (4-HNE), thiobarbituric acid reactive substances (TBARS), and malondialdehyde (MDA)), the total antioxidant status (TAS), and thiol-disulfide homeostasis parameters (TDHP), including total thiol (TT), native thiol (NT), disulfides (DS), DS/NT ratio, DS/TT ratio, and NT/TT ratio. The comparative determinations of serum levels of 4-HNE, TBARS, and MDA in patients with LP (

Indexed as

antioxidantslichen planusoxidative stressreactive metabolic intermediates

Identifiers

PMID31623383
PMCPMC6836031
OpenAlexW2978772509

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.