Evidence map›Paper›PMID 31623310›Full record

ArticleInternational journal of molecular sciences2019

Shielding of Hepatitis B Virus-Like Nanoparticle with Poly(2-Ethyl-2-Oxazoline).

See Yee Fam, Chin Fei Chee, Chean Yeah Yong, Kok Lian Ho, Abdul Razak Mariatulqabtiah, Han Yih Lau, Wen Siang Tan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Stealth Coating of Nanoparticles in Drug-Delivery Systems.Nanomaterials (Basel, Switzerland) · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

See Yee FamDepartment of Microbiology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, Selangor 43400, Malaysia. cyee531@hotmail.com.
Chin Fei CheeNanotechnology and Catalysis Research Centre, University of Malaya, Kuala Lumpur 50603, Malaysia. cheechinfei@um.edu.my.ORCID 0000-0002-5650-9119
Chean Yeah YongDepartment of Microbiology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, Selangor 43400, Malaysia. yongcheanyeah@hotmail.com.ORCID 0000-0002-0842-6386
Kok Lian HoDepartment of Pathology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor 43400, Malaysia. klho@upm.edu.my.ORCID 0000-0002-5778-4729
Abdul Razak MariatulqabtiahDepartment of Cell and Molecular Biology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, Selangor 43400, Malaysia. mariatulqabtiah@upm.edu.my.
Han Yih LauBiotechnology and Nanotechnology Research Centre, Malaysian Agricultural Research and Development Institute (MARDI), Persiaran MARDI-UPM, Serdang 43400, Malaysia. hylau@mardi.gov.my.ORCID 0000-0001-5991-5940
Wen Siang TanDepartment of Microbiology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, Selangor 43400, Malaysia. wstan@upm.edu.my.ORCID 0000-0001-9452-198X

Funding

Universiti Putra Malaysia GP-IPS/2018/9602500
6 · The paper itself

Abstract

Virus-like nanoparticles (VLNPs) have been studied extensively as nanocarriers for targeted drug delivery to cancer cells. However, VLNPs have intrinsic drawbacks, in particular, potential antigenicity and immunogenicity, which hamper their clinical applications. Thus, they can be eliminated easily and rapidly by host immune systems, rendering these nanoparticles ineffective for drug delivery. The aim of this study was to reduce the antigenicity of hepatitis B core antigen (HBcAg) VLNPs by shielding them with a hydrophilic polymer, poly(2-ethyl-2-oxazoline) (PEtOx). In the present study, an amine-functionalized PEtOx (PEtOx-NH

Indexed as

CapsidDrug CarriersDrug Delivery SystemsHepatitis B virusNanoparticlesPolyaminesChemistry Techniques, SyntheticDynamic Light ScatteringHepatitis B Core AntigensMagnetic Resonance SpectroscopyMolecular StructurePolyethylene GlycolsDrug CarriersHepatitis B Core Antigenspoly(2-ethyl-2-oxazoline)PolyaminesPolyethylene Glycolsantigenicityconjugationhepatitis B virus capsidpoly(2-ethyl-2-oxazoline)polymervirus-like particle

Identifiers

PMID31623310
PMCPMC6801929

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.