Evidence map›Paper›PMID 31623303›Full record

ArticleJournal of clinical medicine2019

Early Diagnosis and Classification of Cerebral Palsy: An Historical Perspective and Barriers to an Early Diagnosis.

Anna te Velde, Catherine Morgan, Iona Novak, Esther Tantsis, Nadia Badawi

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05139758 (Correlation Between Anthropometric Measurements And Balance IN Children With Cerebral Palsy), which is not on this map. Cited by 60 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed, 1 pooled it
7.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05139758 naunknown statusnot on this mapstarted 2021, after this paper: background citation

Correlation Between Anthropometric Measurements And Balance IN Children With Cerebral Palsy

TypeinterventionalSponsorCairo UniversityRan2021 to 2022Enrolled60ConditionsAnthropometric Measurements&Balance IN CP ChildrenArmsBiodex Balane System
3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 1 synthesis or guideline pooled it, 150 citations in OpenAlex.

  1. Neural Correlates of Mobility in Children with Cerebral Palsy: A Systematic Review.International journal of environmental research and public health · 2024
    Pooled it
  2. Trial
  3. Standardizing early cerebral palsy detection in high-risk infants: reducing age at diagnosis through a quality improvement initiative.Journal of perinatology : official journal of the California Perinatal Association · 2026
    Article
  4. Article
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  12. Genetic testing in cerebral palsy with clinical and neuroimaging variables.Developmental medicine and child neurology · 2025
    Article
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  14. Observational
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  16. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Anna te VeldeCerebral Palsy Alliance, Discipline of Child and Adolescent Health, Faculty of Medicine and Health, The University of Sydney, New South Wales 2050, Australia. atevelde@cerebralpalsy.org.au.
Catherine MorganCerebral Palsy Alliance, Discipline of Child and Adolescent Health, Faculty of Medicine and Health, The University of Sydney, New South Wales 2050, Australia. cmorgan@cerebralpalsy.org.au.ORCID 0000-0003-3670-0845
Iona NovakCerebral Palsy Alliance, Discipline of Child and Adolescent Health, Faculty of Medicine and Health, The University of Sydney, New South Wales 2050, Australia. inovak@cerebralpalsy.org.au.
Esther TantsisTJ Nelson Department of Neurology & Neurosurgery, The Children's Hospital at Westmead, New South Wales 2145, Australia. esther.tantsis@health.nsw.gov.au.
Nadia BadawiCerebral Palsy Alliance, Discipline of Child and Adolescent Health, Faculty of Medicine and Health, The University of Sydney, New South Wales 2050, Australia. nadia.badawi@health.nsw.gov.au.
The University of Sydney · AUChildren's Hospital at Westmead · AU

Funding

Australasian Cerebral Palsy Clinical Trials Network (AusCP-CTN) NHMRC NUMBER 1116442Australian Rotary Health CDG00318
6 · The paper itself

Abstract

Since the 1800s, there have been calls in the literature for the early diagnosis of cerebral palsy (CP). However, diagnosis still often occurs late, from 12 to 24 months in high income countries and as late as 5 years in low resource settings. This is after the optimal timeframe for applying interventions which could harness neuroplastic potential in the developing brain. Multiple barriers exist which affect clinicians' confidence in diagnosing CP early. These range from the lack of definitive biomarkers to a lack of curative treatments for CP. Further barriers to diagnosis are proposed including; (a) difficulty finding a congruent fit with the definition of CP in an infant, where expected activity limitations might not yet be apparent; and (b) differences in the presentation of motor type and topography classifications between infants and children. These barriers may affect a clinicians' confidence using "pattern recognition" in the differential diagnosis process. One of the central tenets of this paper is that diagnosis and classification are different, involving different instruments, and are more accurately conducted separately in infants, whereas they are fundamentally interconnected in older children and inform therapeutic decisions. Furthermore, we need to be careful not to delay early diagnosis because of the low reliability of early classification, but instead uncouple these two processes. Ongoing implementation of best practice for early detection requires creative solutions which might include universal screening for CP. Implementation and accompanying knowledge translation studies are underway to decrease the average age of diagnosis in CP.

Indexed as

cerebral palsyclassificationearly detectionearly diagnosisinfantsmotor typepattern recognitionseveritytopography

Identifiers

PMID31623303
PMCPMC6832653
OpenAlexW2978492093

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.