Evidence map›Paper›PMID 31623224›Full record

ReviewJournal of clinical medicine2019

NK Cell-Based Immunotherapy for Hematological Malignancies.

Simona Sivori, Raffaella Meazza, Concetta Quintarelli, Simona Carlomagno, Mariella Della Chiesa, Michela Falco, Lorenzo Moretta, Franco Locatelli, Daniela Pende

Open access · goldAbstract readReview
In one paragraph

Review in Journal of clinical medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 68 citations in OpenAlex.

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  13. AutologousAmerican journal of translational research · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Simona SivoriDepartment of Experimental Medicine, University of Genoa, 16132 Genoa, Italy.
Raffaella MeazzaDepartment of Integrated Oncological Therapies, IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy. raffaella.meazza@hsanmartino.it.ORCID 0000-0003-0242-3157
Concetta QuintarelliDepartment of Hematology/Oncology, IRCCS Ospedale Pediatrico Bambino Gesù, 00165 Rome, Italy. concetta.quintarelli@opbg.net.
Simona CarlomagnoDepartment of Experimental Medicine, University of Genoa, 16132 Genoa, Italy. Simona.Carlomagno@unige.it.
Mariella Della ChiesaDepartment of Experimental Medicine, University of Genoa, 16132 Genoa, Italy. Mariella.DellaChiesa@unige.it.
Michela FalcoIntegrated Department of Services and Laboratories, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy. michelaemma.falco@gmail.com.
Lorenzo MorettaDepartment of Immunology, IRCCS Ospedale Pediatrico Bambino Gesù, 00146 Rome, Italy. lorenzo.moretta@opbg.net.
Franco LocatelliDepartment of Hematology/Oncology, IRCCS Ospedale Pediatrico Bambino Gesù, 00165 Rome, Italy. franco.locatelli@opbg.net.
Daniela PendeDepartment of Integrated Oncological Therapies, IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy. daniela.pende@hsanmartino.it.ORCID 0000-0003-1565-451X
Bambino Gesù Children's Hospital · ITUniversity of Genoa · ITOspedale Policlinico San Martino · ITIstituto Giannina Gaslini · IT

Funding

Accelerator Award 2017 INCARAssociazione Italiana per la Ricerca sul Cancro 16764Associazione Italiana per la Ricerca sul Cancro 19920Associazione Italiana per la Ricerca sul Cancro 20312Associazione Italiana per la Ricerca sul Cancro 21147Associazione Italiana per la Ricerca sul Cancro 21724H2020 Marie Skłodowska-Curie Actions ITN-2017-765104Ministero della Salute GR-2013-02359212Ministero della Salute RF-2016-02364388Ministero dell'Istruzione, dell'Università e della Ricerca PRIN-2017WC8499_004
6 · The paper itself

Abstract

Natural killer (NK) lymphocytes are an integral component of the innate immune system and represent important effector cells in cancer immunotherapy, particularly in the control of hematological malignancies. Refined knowledge of NK cellular and molecular biology has fueled the interest in NK cell-based antitumor therapies, and recent efforts have been made to exploit the high potential of these cells in clinical practice. Infusion of high numbers of mature NK cells through the novel graft manipulation based on the selective depletion of T cells and CD19

Indexed as

acute leukemiaCAR-NK cellscytokineshematopoietic stem cell transplantationHLA class Iimmunotherapykiller immunoglobulin-like receptorsNK cell alloreactivityNK cellsreceptors

Identifiers

PMID31623224
PMCPMC6832127
OpenAlexW2981234956

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.