Evidence map›Paper›PMID 31623223›Full record

ArticleNutrients2019

Effects of Long-Versus Short-Term Exposure to the Mediterranean Diet on Skin Microvascular Function and Quality of Life of Healthy Adults in Greece and the UK.

Markos Klonizakis, Maria G Grammatikopoulou, Xenophon Theodoridis, Marianne Milner, Yingshan Liu, Michael Chourdakis

Abstract readControlled Clinical TrialMulticenter Study
In one paragraph

Article in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Human gut microbiome, diet, and mental disorders.International microbiology : the official journal of the Spanish Society for Microbiology · 2025
    Review
  4. Article
  5. Article
  6. Diet in Scleroderma: Is There a Need for Intervention?Diagnostics (Basel, Switzerland) · 2021
    Article
  7. Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Markos KlonizakisDepartment of Nursing and Midwifery, Faculty of Health and Wellbeing, Sheffield Hallam University, Sheffield S10 2BP, UK. m.klonizakis@shu.ac.uk.ORCID 0000-0002-8864-4403
Maria G GrammatikopoulouDepartment of Nutritional Sciences & Dietetics, International Hellenic University, PO Box 141, Sindos, GR57400 Thessaloniki, Greece. maria@nutr.teithe.gr.ORCID 0000-0003-4167-6595
Xenophon TheodoridisLaboratory of Hygiene, Social & Preventive Medicine and Medical Statistics, Department of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, University Campus, GR54124 Thessaloniki, Greece. xenofontheodoridis@gmail.com.
Marianne MilnerDepartment of Nursing and Midwifery, Faculty of Health and Wellbeing, Sheffield Hallam University, Sheffield S10 2BP, UK. mariannebmilner@gmail.com.
Yingshan LiuDepartment of Nursing and Midwifery, Faculty of Health and Wellbeing, Sheffield Hallam University, Sheffield S10 2BP, UK. liuyingshan_sylvia@hotmail.com.
Michael ChourdakisLaboratory of Hygiene, Social & Preventive Medicine and Medical Statistics, Department of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, University Campus, GR54124 Thessaloniki, Greece. mhourd@gapps.auth.gr.

Funding

Sheffield Hallam University DIRF Fellowship
6 · The paper itself

Abstract

The beneficial effects of the Mediterranean diet (MD) adherence in reducing cardiovascular disease (CVD) risk and improving CVD-related physiological indices have been well-documented. However, the exact MD adherence duration needed for these effects to occur is under-researched. The aim of the present, two-arm, two-site study clinical trial was to assess the effects of long- vs. short-term MD adherence on the skin microvascular circulation, and quality of life. Two groups were recruited, one being long-term MD adherers (>5 years; from Greece; control group), and one of the non-adherers (from the UK), with the latter participating in a four-week MD intervention (intervention group). Our main outcome was skin microvascular function assessed by cutaneous vascular conductance (CVC). Secondary outcomes included quality of life, dietary intake, blood pressure and lipidemic profile. At the end of the intervention, both groups had high MD adherence. For the intervention group, significantly improved post-intervention CVC values were noted concerning the initial peak phase (2.0 ± 0.6 vs. 2.8 ± 0.8;

Indexed as

Diet, HealthyDiet, MediterraneanMicrocirculationQuality of LifeAdolescentAdultAgedBiomarkersCardiovascular DiseasesEnergy IntakeEnglandFemaleGreeceHumansLipidsMaleBiomarkersLipidscardiovascular diseaseclinical trialdietary interventionMediterranean dietmicrocirculationnutrition therapyquality of life

Identifiers

PMID31623223
PMCPMC6835788

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.