Evidence map›Paper›PMID 31623184›Full record

Trial reportNutrients2019

The In Vivo Net Energy Content of Resistant Starch and Its Effect on Macronutrient Oxidation in Healthy Adults.

Erin D Giles, Ian L Brown, Paul S MacLean, Zhaoxing Pan, Edward L Melanson, Kennon J Heard, Marc-Andre Cornier, Tyson Marden, Janine A Higgins

Open access · goldAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 17 citations in OpenAlex.

  1. Prebiotics pectin and resistant starch-type 4 stimulate peptide YY and cholecystokinin to promote satiety, and improve gut microbiota composition.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  2. Article
  3. Effects of different starch structures on energy metabolism in pigs.Journal of animal science and biotechnology · 2023
    Article
  4. Review
  5. Metabolic Responses to Native Wheat Starch (MidsolCurrent developments in nutrition · 2021
    Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Erin D GilesDepartment of Nutrition & Food Science, Texas A&M University, College Station, TX 77843, USA. egiles@tamu.edu.
Ian L BrownAustralian Cancer Research Foundation, Sydney 2001, Australia. mrbmrsb1@gmail.com.
Paul S MacLeanDivision of Endocrinology, Metabolism, and Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA. Paul.MacLean@CUANSCHUTZ.EDU.
Zhaoxing PanDepartment of Pediatrics, Endocrinology Section, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA. Zhaoxing.Pan@CUANSCHUTZ.EDU.
Edward L MelansonDivision of Endocrinology, Metabolism, and Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA. Ed.Melanson@CUANSCHUTZ.EDU.
Kennon J HeardDepartment of Emergency Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA. KENNON.HEARD@CUANSCHUTZ.EDU.
Marc-Andre CornierDivision of Endocrinology, Metabolism, and Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA. Marc.Cornier@CUANSCHUTZ.EDU.
Tyson MardenColorado Clinical and Translational Sciences Institute, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA. TYSON.MARDEN@CUANSCHUTZ.EDU.ORCID 0000-0001-6258-1267
Janine A HigginsDepartment of Pediatrics, Endocrinology Section, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA. Janine.Higgins@childrenscolorado.org.ORCID 0000-0002-8677-2831
University of Colorado Anschutz Medical Campus · USGeriatric Research Education and Clinical Center · USAustralian Cancer Research Foundation · AUColorado School of Public Health · USTexas A&M University · US

Funding

NIH Prior Approval Process ProfessionalUL1TR002535 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2018 to 2022
$51.1M
PILOT STUDY--SUBSTRATE METABOLISM IN EXTREMELY LOW BIRTH WEIGHT INFANTSP30DK048520 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI Wendy M Kohrt · 1995 to 2026
$32.6M
Why is the prevalence of obesity so high in U.S. Southern States? Regional predictors of BMI and obesity treatment response.P30DK056336 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI James O Hill · 2000 to 2026
$31.9M
University of Alabama at Birmingham's Diabetes Research CenterP30DK079626 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Kirk Michael Habegger · 2013 to 2026
$19.5M
Sex hormones and arthritis in a long lived animal modelP30AG050886 · NIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Jianhua Zhang · 2015 to 2026
$11.3M
Imperial Chemicals Industries PLC, London EnglandNCATS NIH HHS UL1 TR002535NIA NIH HHS P30 AG050886NIDDK NIH HHS P30 DK048520NIDDK NIH HHS P30 DK056336NIH HHS P30AG050886NIH HHS P30 DK048520-24NIH HHS P30DK056336NIH HHS P30DK079626NIH HHS UL1TR002535
6 · The paper itself

Abstract

The in vivo net energy content of resistant starch (RS) has not been measured in humans so it has not been possible to account for the contribution of RS to dietary energy intake. We aimed to determine the in vivo net energy content of RS and examine its effect on macronutrient oxidation. This was a randomized, double-blind cross-over study. Eighteen healthy adults spent 24 h in a whole room indirect calorimeter to measure total energy expenditure (TEE), substrate oxidation, and postprandial metabolites in response to three diets: 1) digestible starch (DS), 2) RS (33% dietary fiber; RS), or 3) RS with high fiber (RSF, 56% fiber). The in vivo net energy content of RS and RSF are 2.74 ± 0.41 and 3.16 ± 0.27 kcal/g, respectively. There was no difference in TEE or protein oxidation between DS, RS, and RSF. However, RS and RSF consumption caused a 32% increase in fat oxidation (

Indexed as

Energy IntakeNutritive ValueAdultBiomarkersBlood GlucoseColoradoCross-Over StudiesDietary CarbohydratesDietary FatsDietary ProteinsDouble-Blind MethodFemaleHealthy VolunteersHumansInsulinInsulin ResistanceBiomarkersBlood GlucoseDietary CarbohydratesDietary FatsDietary ProteinsInsulinStarchTriglyceridescarbohydrate oxidationenergy expenditurefat oxidationfiberfood labelingin vivonet energyresistant starch

Identifiers

PMID31623184
PMCPMC6835355
OpenAlexW2981092676

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.