Evidence map›Paper›PMID 31623163›Full record

ReviewCancers2019

The Complexities of Metastasis.

Beatriz P San Juan, Maria J Garcia-Leon, Laura Rangel, Jacky G Goetz, Christine L Chaffer

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cancers, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Beatriz P San JuanThe Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst 2010, Australia. b.perez@garvan.org.au.
Maria J Garcia-LeonINSERM UMR_S1109, Tumor Biomechanics, 67000 Strasbourg, France. m.garcia@inserm.fr.
Laura RangelThe Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst 2010, Australia. l.rangel@garvan.org.au.ORCID 0000-0003-4011-577X
Jacky G GoetzINSERM UMR_S1109, Tumor Biomechanics, 67000 Strasbourg, France. jacky.goetz@inserm.fr.
Christine L ChafferThe Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst 2010, Australia. c.chaffer@garvan.org.au.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Therapies that prevent metastatic dissemination and tumor growth in secondary organs are severely lacking. A better understanding of the mechanisms that drive metastasis will lead to improved therapies that increase patient survival. Within a tumor, cancer cells are equipped with different phenotypic and functional capacities that can impact their ability to complete the metastatic cascade. That phenotypic heterogeneity can be derived from a combination of factors, in which the genetic make-up, interaction with the environment, and ability of cells to adapt to evolving microenvironments and mechanical forces play a major role. In this review, we discuss the specific properties of those cancer cell subgroups and the mechanisms that confer or restrict their capacity to metastasize.

Indexed as

biomechanicscirculating tumor cells (CTCs), extracellular vesiclesCTC-clustersepigeneticsepithelial-to-mesenchymal transitionheterogeneitymetastasismetastatic nicheplasticity

Identifiers

PMID31623163
PMCPMC6826702

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.