Evidence map›Paper›PMID 31623150›Full record

ArticleInternational journal of molecular sciences2019

miR-7 Knockdown by Peptide Nucleic Acids in the Ascidian

Silvia Mercurio, Silvia Cauteruccio, Raoul Manenti, Simona Candiani, Giorgio Scarì, Emanuela Licandro, Roberta Pennati

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Designer Biopolymers: Self-Assembling Proteins and Nucleic Acids.International journal of molecular sciences · 2020
    Article
  8. Exploring miR-9 Involvement inInternational journal of molecular sciences · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Silvia MercurioDepartment of Environmental Science and Policy, Università degli Studi di Milano, 20133 Milano, Italy. sil.mercurio@gmail.com.ORCID 0000-0002-2587-8237
Silvia CauteruccioDepartment of Chemistry, Università degli Studi di Milano, 20133 Milano, Italy. silvia.cauteruccio@unimi.it.
Raoul ManentiDepartment of Environmental Science and Policy, Università degli Studi di Milano, 20133 Milano, Italy. raoul.manenti@unimi.it.ORCID 0000-0001-6071-8194
Simona CandianiDepartment of Earth Science, Environment and Life, Università degli Studi di Genova, 16126 Genova, Italy. simona.candiani@unige.it.ORCID 0000-0002-4453-5475
Giorgio ScarìDepartment of Biosciences, Università degli Studi di Milano, 20133 Milano, Italy. nkiller@unimi.it.
Emanuela LicandroDepartment of Chemistry, Università degli Studi di Milano, 20133 Milano, Italy. emanuela.licandro@unimi.it.
Roberta PennatiDepartment of Environmental Science and Policy, Università degli Studi di Milano, 20133 Milano, Italy. roberta.pennati@unimi.it.
University of Milan · ITUniversity of Genoa · IT

Funding

Fondazione Cariplo 2013-0752
6 · The paper itself

Abstract

Peptide Nucleic Acids (PNAs) are synthetic mimics of natural oligonucleotides, which bind complementary DNA/RNA strands with high sequence specificity. They display numerous advantages, but in vivo applications are still rare. One of the main drawbacks of PNAs application is the poor cellular uptake that could be overcome by using experimental models, in which microinjection techniques allow direct delivery of molecules into eggs. Thus, in this communication, we investigated PNAs efficiency in miR-7 downregulation and compared its effects with those obtained with the commercially available antisense molecule, Antagomir (Dharmacon) in the ascidian

Indexed as

Gene Knockdown TechniquesAnimalsBiomarkersCiona intestinalisGene Expression ProfilingGene SilencingImmunohistochemistryMicroRNAsMolecular StructureOligonucleotidesPeptide Nucleic AcidsBiomarkersMicroRNAsOligonucleotidesPeptide Nucleic AcidshnRNP KLNA probemicroRNAPNAtunicates

Identifiers

PMID31623150
PMCPMC6829576
OpenAlexW2981290819

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.