Evidence map›Paper›PMID 31623079›Full record

ArticleNutrients2019

Cord Blood-Derived Exosomal CNTN2 and BDNF: Potential Molecular Markers for Brain Health of Neonates at Risk for Iron Deficiency.

Paulina S Marell, Sharon E Blohowiak, Michael D Evans, Michael K Georgieff, Pamela J Kling, Phu V Tran

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Anemia, Iron Supplementation, and the Brain.Clinics in perinatology · 2023
    Review
  6. Biosensors, Recent Advances in Determination of BDNF and NfL.Cellular and molecular neurobiology · 2023
    Review
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Review
  13. Review
  14. Urinary ferritin; a potential noninvasive way to screen NICU patients for iron deficiency.Journal of perinatology : official journal of the California Perinatal Association · 2021
    Article
  15. Function of Drosophila Synaptotagmins in membrane trafficking at synapses.Cellular and molecular life sciences : CMLS · 2021
    Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Paulina S MarellDepartment of Pediatrics, Medical School, University of Minnesota, Minneapolis, MN 55455, USA. marel011@umn.edu.
Sharon E BlohowiakDepartment of Pediatrics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53715, USA. sblohowiak@pediatrics.wisc.edu.
Michael D EvansClinical and Translational Science Institute, University of Minnesota, Minneapolis, MN 55455, USA. evan0262@umn.edu.ORCID 0000-0001-7449-3993
Michael K GeorgieffDepartment of Pediatrics, Medical School, University of Minnesota, Minneapolis, MN 55455, USA. georg001@umn.edu.
Pamela J KlingDepartment of Pediatrics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53715, USA. pkling@wisc.edu.
Phu V TranDepartment of Pediatrics, Medical School, University of Minnesota, Minneapolis, MN 55455, USA. tranx271@umn.edu.ORCID 0000-0002-4301-941X
University of Minnesota Medical Center · USUniversity of Wisconsin–Madison · USUniversity of Minnesota · US

Funding

University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UL1TR002494 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R, WEISDORF, DANIEL J · 2018 to 2022
$34.9M
Gerber Foundation PK UWiscNIH's National Center for Advancing Translational Sciences UL1TR002494
6 · The paper itself

Abstract

Maternal iron deficiency anemia, obesity, and diabetes are prevalent during pregnancy. All are associated with neonatal brain iron deficiency (ID) and neurodevelopmental impairment. Exosomes are extracellular vesicles involved in cell-cell communication. Contactin-2 (CNTN2), a neural-specific glycoprotein, and brain-derived neurotrophic factor (BDNF) are important in neurodevelopment and found in exosomes. We hypothesized that exosomal CNTN2 and BDNF identify infants at risk for brain ID. Umbilical cord blood samples were measured for iron status. Maternal anemia, diabetes, and body mass index (BMI) were recorded. Cord blood exosomes were isolated and validated for the exosomal marker CD81 and the neural-specific exosomal marker CNTN2. Exosomal CNTN2 and BDNF levels were quantified by ELISA. Analysis of CNTN2 and BDNF levels as predictors of cord blood iron indices showed a direct correlation between CNTN2 and ferritin in all neonates (

Indexed as

AdolescentAdultAnemia, Iron-DeficiencyBiomarkersBrainBrain-Derived Neurotrophic FactorContactin 2ExosomesFemaleFerritinsFetal BloodHumansInfant, NewbornMalePregnancyRisk FactorsBDNF protein, humanBiomarkersBrain-Derived Neurotrophic FactorCNTN2 protein, humanContactin 2Ferritinsbraindiabetesneurodevelopmentnutritionobesity

Identifiers

PMID31623079
PMCPMC6835945
OpenAlexW2980372970

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.