ArticleProceedings of the National Academy of Sciences of the United States of America1988
Two genetic loci participate in the regulation by iron of the gene for the human transferrin receptor.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 94 citations in OpenAlex.
- The DMT1 IVS4+44C>A polymorphism and the risk of iron deficiency anemia in children with celiac disease.PloS one · 2017Trial
- Article
- Mapping the genetic landscape of iron metabolism uncovers the SETD2 methyltransferase as a modulator of iron flux.Science advances · 2025Article
- SIREs 3.0, an improved RNA prediction tool for iron-responsive elements.Nucleic acids research · 2025Article
- Iron-mediated post-transcriptional regulation in Toxoplasma gondii.PLoS pathogens · 2025Article
- Iron-dependent post transcriptional control of mitochondrial aconitase expression.Metallomics : integrated biometal science · 2023Article
- Roquin is a major mediator of iron-regulated changes to transferrin receptor-1 mRNA stability.iScience · 2021Article
- Article
- Mammalian iron transport.Cellular and molecular life sciences : CMLS · 2009Review
- Liver iron transport.World journal of gastroenterology · 2007Review
- Molecular control of vertebrate iron homeostasis by iron regulatory proteins.Biochimica et biophysica acta · 2006Review
- Inhibition of transferrin receptor 1 transcription by a cell density response element.The Biochemical journal · 2005Article
- Previously uncharacterized isoforms of divalent metal transporter (DMT)-1: implications for regulation and cellular function.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Conditional derepression of ferritin synthesis in cells expressing a constitutive IRP1 mutant.Molecular and cellular biology · 2002Article
- Bacillus subtilis aconitase is an RNA-binding protein.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress.Proceedings of the National Academy of Sciences of the United States of America · 1996Review
- Defining a novel cis element in the 3'-untranslated region of mammalian ribonucleotide reductase component R2 mRNA: role in transforming growth factor-beta 1 induced mRNA stabilization.Nucleic acids research · 1995Article
- Nitric oxide signaling to iron-regulatory protein: direct control of ferritin mRNA translation and transferrin receptor mRNA stability in transfected fibroblasts.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- Defining a novel ribonucleotide reductase r1 mRNA cis element that binds to an unique cytoplasmic trans-acting protein.Nucleic acids research · 1994Article
- The bifunctional iron-responsive element binding protein/cytosolic aconitase: the role of active-site residues in ligand binding and regulation.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
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5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Iron regulation of the human transferrin receptor gene was examined in murine cells transformed with chimeric constructs containing the human transferrin receptor gene's promoter and either the structural gene for bacterial chloramphenicol acetyltransferase or the human transferrin receptor cDNA. The activity of the transferrin receptor gene's promoter with the heterologous indicator gene was found to be approximately equal to 3-fold higher in cells treated with the iron chelator desferrioxamine than in cells treated with the iron source, hemin. A higher degree of iron regulation was seen in the expression of the human transferrin receptor cDNA driven by its own promoter. The receptor cDNA under the control of the simian virus 40 early promoter was also iron-regulated. Several human transferrin receptor transcripts differing in their 3' end were produced in the murine cells regardless of the promoter used, with the shorter transcripts being relatively unregulated by iron. Deletion of cDNA corresponding to most of the 3' untranslated portion of the mRNA for the receptor ablated the iron regulation. We conclude that at least two genetic elements exist for the regulation of the transferrin receptor gene by iron. One has its locus in the DNA upstream of the transferrin receptor gene's transcription start site, and the other is dependent upon the integrity of the sequences in the 3' end of the gene.
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