ArticleJournal of hazardous materials2020
Prevalence of illicit and prescribed neuropsychiatric drugs in three communities in Kentucky using wastewater-based epidemiology and Monte Carlo simulation for the estimation of associated uncertainties.
Article in Journal of hazardous materials, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 81 citations in OpenAlex.
- Current state and future perspectives on de facto population markers for normalization in wastewater-based epidemiology: A systematic literature review.The Science of the total environment · 2024Pooled it
- Wastewater-based surveillance for community exposome surveillance, Louisville, Kentucky.Discover water · 2026Article
- Development of an HPLC-HRMS Method for the Identification and Semi-Quantitation in River Water Samples of the Transformation Products Originated From Heterogeneous Photocatalysis of Antipsychotic Drugs.Journal of separation science · 2025Article
- Wastewater Surveillance for Xylazine in Kentucky.AJPM focus · 2024Article
- Target and Nontarget Screening to Support Capacity Scaling for Substance Use Assessment through a Statewide Wastewater Surveillance Network in New York.Environmental science & technology · 2024Article
- Fate-and-transport modeling of SARS-CoV-2 for rural wastewater-based epidemiology application benefit.Heliyon · 2024Article
- Population infection estimation from wastewater surveillance for SARS-CoV-2 in Nagpur, India during the second pandemic wave.PloS one · 2024Article
- Trends and challenges in analytical chemistry for multi-analysis of illicit drugs employing wastewater-based epidemiology.Analytical and bioanalytical chemistry · 2023Article
- Long-term wastewater-based surveillance and impacts of the COVID-19 pandemic on drug use trends in a U.S. Northeast rural town.The Science of the total environment · 2023Article
- Knowledge graph of wastewater-based epidemiology development: A data-driven analysis based on research topics and trends.Environmental science and pollution research international · 2023Review
- Wastewater-based epidemiology: a new frontier for tracking environmental persistence and community transmission of COVID-19.Environmental science and pollution research international · 2022Review
- Modeling the number of people infected with SARS-COV-2 from wastewater viral load in Northwest Spain.The Science of the total environment · 2022Article
- Nationwide public perceptions regarding the acceptance of using wastewater for community health monitoring in the United States.PloS one · 2022Article
- Uncertainties in estimating SARS-CoV-2 prevalence by wastewater-based epidemiology.Chemical engineering journal (Lausanne, Switzerland : 1996) · 2021Review
- Gene alteration in zebrafish exposed to a mixture of substances of abuse.Environmental pollution (Barking, Essex : 1987) · 2021Article
- Wastewater analysis reveals urban, suburban, and rural spatial patterns of illicit drug use in Dalian, China.Environmental science and pollution research international · 2021Article
- Isoprostanes in wastewater as biomarkers of oxidative stress during COVID-19 pandemic.Chemosphere · 2021Article
- Estimating drug consumption during a college sporting event from wastewater using liquid chromatography mass spectrometry.The Science of the total environment · 2021Article
- Basketball and drugs: Wastewater-based epidemiological estimation of discharged drugs during basketball games in Kentucky.The Science of the total environment · 2021Article
- Occurrence and Mass Loading of Synthetic Opioids, Synthetic Cathinones, and Synthetic Cannabinoids in Wastewater Treatment Plants in Four U.S. Communities.Environmental science & technology · 2020Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
A cost-effective alternative approach capable of determining the prevalence of substance use in communities can complement the existing efforts of combating drug abuse and addiction. In this study, the prevalence of 10 illicit and 19 prescribed psychoactive drugs of potential abuse was determined utilizing wastewater-based epidemiology, and compared in two adjoined urban communities and a rural community. This is the first application of the Monte Carlo simulation method to account multiple uncertainties and propagation of errors associated with the individual parameter of wastewater based epidemiological estimations in the U.S. A significantly higher prevalence of cocaine [3830 (mean difference, MD: 2960) mg/d/1000 people] was found in the central business district while the per-capita consumption rates of amphetamine [738 (MD: 338) mg/d/1000 people] and methamphetamine [1660 (MD: 629) mg/d/1000 people] were higher in a rural community. Among narcotics, the per-capita consumption rate of fentanyl and morphine was significantly higher in urban communities while codeine, hydrocodone, hydromorphone, and buprenorphine were dominant in a rural community. The significantly higher prevalence of buprenorphine (˜20-30 folds), oxycodone (˜2-3 folds), and alprazolam (˜2-3 folds) determined in these communities compared to the conventional estimates based on the electronically reported prescriptions and drug-related inpatient hospitalizations suggest the abuse of these drugs.
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Registered trials
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