Evidence map›Paper›PMID 31622841›Full record

ArticleNeuroImage. Clinical2019

Magnetic resonance imaging of the cervical spinal cord in spinal muscular atrophy.

Marloes Stam, Wieke Haakma, Lidy Kuster, Martijn Froeling, Marielle E P Philippens, Clemens Bos, Alexander Leemans, Louise A M Otto, Leonard H van den Berg, Jeroen Hendrikse and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage. Clinical, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Marloes StamUMC Utrecht Brain Center, Department of Neurology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Wieke HaakmaDepartment of Radiology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Lidy KusterDepartment of Radiology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Martijn FroelingDepartment of Radiology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Marielle E P PhilippensDepartment of Radiotherapy, Cancer Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Clemens BosDepartment of Radiology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Alexander LeemansImage Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands.
Louise A M OttoUMC Utrecht Brain Center, Department of Neurology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Leonard H van den BergUMC Utrecht Brain Center, Department of Neurology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Jeroen HendrikseDepartment of Radiology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
W Ludo van der PolUMC Utrecht Brain Center, Department of Neurology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands. Electronic address: W.L.vanderPol@umcutrecht.nl.
Utrecht University · NLUniversity Medical Center Utrecht · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveIn this study we investigated the potential value of magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI) in characterizing changes in the cervical spinal cord and peripheral nerve roots in vivo in patients with spinal muscular atrophy (SMA).

methodsWe developed an MRI protocol with 4 sequences to investigate the cervical spinal cord and nerve roots on a 3 Tesla MRI system. We used 2 anatomical MRI sequences to investigate cross-sectional area (CSA) at each spinal segment and the diameter of ventral and dorsal nerve roots, and two diffusion tensor imaging (DTI) techniques to estimate the fractional anisotropy (FA), mean (MD), axial (AD) and radial diffusivity (RD) in 10 SMA patients and 20 healthy controls.

resultsThere were no significant differences in CSA (p > .1), although an 8.5% reduction of CSA in patients compared to healthy controls was apparent at segment C7. DTI data showed a higher AD in grey matter of patients compared to healthy controls (p = .033). Significantly lower MD, AD and RD values were found in rostral nerve roots (C3-C5) in patients (p < .045).

conclusionsWe showed feasibility of an advanced 3 T MRI protocol that allowed differences to be determined between patients and healthy controls, confirming the potential of this technique to assess pathological mechanisms in SMA. After further development and confirmation of findings in a larger sample, these techniques may be used to study disease course of SMA in vivo and evaluate response to survival motor neuron (SMN) augmenting therapy.

Indexed as

AdolescentAdultAgedCervical CordDiffusion Tensor ImagingFeasibility StudiesFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedMuscular Atrophy, SpinalSpinal Nerve RootsYoung AdultDTIMRINerve rootsSMASpinal cordSpinal muscular atrophy

Identifiers

PMID31622841
PMCPMC6812296
OpenAlexW2971756469

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.