ArticleNeuroImage. Clinical2019
Dysfunction between dorsal caudate and salience network associated with impaired cognitive flexibility in obsessive-compulsive disorder: A resting-state fMRI study.
Article in NeuroImage. Clinical, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Exploring functional connectivity in large-scale brain networks in obsessive-compulsive disorder: a systematic review of EEG and fMRI studies.Cerebral cortex (New York, N.Y. : 1991) · 2024Pooled it
- Trial
- Altered seed-to-whole-brain functional connectivity of goal-directed/habitual systems in obsessive-compulsive disorder: associated genes and preliminary classification potential.European archives of psychiatry and clinical neuroscience · 2026Article
- A diffusion MRI-based structural assessment of the striatal compartments, striosome and matrix, in Obsessive Compulsive Disorder.Research square · 2026Article
- Obsessive-compulsive tendencies shift the balance between competitive neurocognitive functions.iScience · 2026Article
- Neural mechanisms underlying cognitive inflexibility in obsessive-compulsive disorder: a review.Frontiers in psychiatry · 2026Review
- Neural fingerprints of data driven cognitive subtypes across the psychosis spectrum: a B-SNIP study.Translational psychiatry · 2025Article
- Baseline Functional Connectivity of the Mesolimbic, Salience, and Sensorimotor Systems Predicts Responses to Psychological Therapies for Chronic Low Back Pain With Comorbid Depression: A Functional MRI Study.Brain and behavior · 2025Article
- Cerebellocerebral connectivity predicts body mass index: a new open-source Python-based framework for connectome-based predictive modeling.GigaScience · 2025Article
- Diffusion Magnetic Resonance Imaging Tractography Guides Investigation of the Zona Incerta: A Novel Target for Deep Brain Stimulation.Biological psychiatry · 2024Article
- Convergent functional change of frontoparietal network in obsessive-compulsive disorder: a voxel-based meta-analysis.Frontiers in psychiatry · 2024Review
- Resting state network connectivity is associated with cognitive flexibility performance in youth in the Adolescent Brain Cognitive Development Study.Neuropsychologia · 2023Article
- Disorder-specific cingulo-opercular network hyperconnectivity in pediatric OCD relative to pediatric anxiety.Psychological medicine · 2023Article
- Increased functional connectivity between presupplementary motor area and inferior frontal gyrus associated with the ability of motor response inhibition in obsessive-compulsive disorder.Human brain mapping · 2022Article
- Inverse Association Between Resting-State Putamen Activity and Iowa Gambling Task Performance in Patients With Obsessive-Compulsive Disorder and Control Subjects.Frontiers in psychiatry · 2022Article
- Altered resting state functional connectivity in youth with congenital heart disease operated during infancy.PloS one · 2022Article
- Contrasting dorsal caudate functional connectivity patterns between frontal and temporal cortex with BMI increase: link to cognitive flexibility.International journal of obesity (2005) · 2021Article
- The Legacy of the TTASAAN Report-Premature Conclusions and Forgotten Promises: A Review of Policy and Practice Part I.Frontiers in neurology · 2021Review
- Aberrant Resting-State Cerebellar-Cerebral Functional Connectivity in Unmedicated Patients With Obsessive-Compulsive Disorder.Frontiers in psychiatry · 2021Article
- Sex differences in functional network dynamics observed using coactivation pattern analysis.Cognitive neuroscienceArticle
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundImpaired cognitive flexibility has been implicated in the genetic basis of obsessive-compulsive disorder (OCD). Recent endophenotype studies of OCD showed neural inefficiency in the cognitive control network and interference by the limbic network of the cognitive control network. Exploring the relationship between the functional brain network and impaired cognitive flexibility may provide novel information about the neurobiological basis of OCD.
methodsWe obtained resting-state functional magnetic resonance imaging (rsfMRI) scans and measured the cognitive flexibility of 37 medication-free OCD patients and 40 healthy control (HC) participants using the Wisconsin Card Sorting Test (WCST). We explored the difference between OCD and HC groups in the functional brain network related to impaired cognitive flexibility from the amygdala and dorsal striatal regions of interest (ROIs) by using a seed-based approach.
resultsSignificant differences between the OCD and HC groups were identified in the resting state functional network from the dorsal caudate. Increased functional connectivity from the dorsal caudate to the dorsal anterior cingulate cortex (dACC) and anterior insula (AI) was associated with poorer cognitive flexibility in the OCD group, but better cognitive flexibility in the HC group.
conclusionsThese results provide evidence that the impaired cognitive flexibility of OCD may be associated with dysfunctions of the brain network from the dorsal caudate (DC) to important nodes of the salience network. Our results extend the neuropsychological model of OCD by showing intrinsically different associations between OCD and HC in functional network and cognitive flexibility.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.